PMID: 6408272May 1, 1983Paper

Respiratory quotient and patterns of substrate utilization in human sepsis and trauma

JPEN. Journal of Parenteral and Enteral Nutrition
I GiovanniniG C Castiglioni

Abstract

Three hundred measurements of indirect calorimetric and hemodynamic variables were performed in 99 critically ill septic and nonseptic surgical patients. Septics manifested, with respect to nonseptics, higher O2 consumption, metabolic rate and cardiac index, and lower respiratory quotient in the presence of higher glucose infusion rates and glucose infusion rate/metabolic rate ratios. Among septics there was a group of more severely ill patients with signs of multiple organ failure who manifested a dissociated pattern characterized by a tendency to decreased O2 consumption in the presence of increasing cardiac index and central venous O2 partial pressure: they had higher respiratory quotients, with respect to the other septics, for a given glucose infusion rate/metabolic rate ratio. The lower mean respiratory quotient of septics indicates that they depend generally more than nonseptic trauma patients on fat as an energy substrate and confirms a previously obtained evidence of limited hepatic lipogenesis in sepsis. At the same time, however, it is suggested that fat utilization becomes impaired (and hepatic lipogenesis becomes prominent) in sepsis at a stage in which signs of impaired oxidative metabolism and major metabolic abn...Continue Reading

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Citations

Jul 26, 2013·Science Translational Medicine·Raymond J LangleyStephen F Kingsmore
Apr 1, 1987·World Journal of Surgery·F B Cerra
Nov 1, 1986·Mayo Clinic Proceedings·C F AndersonK E Moxness
Oct 16, 2009·Journal of Critical Care·Carlo ChiarlaGennaro Nuzzo
Dec 1, 1984·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·W HartlG Dietze
Sep 24, 2013·The Journal of Surgical Research·Sean P WhelanBrian S Zuckerbraun
Jul 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·G NanniM Castagneto
Jul 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·C L Long
Nov 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·H MochizukiJ W Alexander
Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·I GiovanniniM Castagneto
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·W ParkH Helge
Nov 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·M JeevanandamS R Petersen
Sep 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·R R Williams, C R Fuenning
Mar 1, 1986·Angiology·I GiovanniniC Chiarla
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·R H Bower
Jun 30, 2018·Critical Care Medicine·Craig M CoopersmithAndrew Rhodes
Nov 30, 2018·Journal of Applied Physiology·Matthew N Cramer, Ollie Jay
Jun 1, 1999·Current Opinion in Pediatrics·A Pierro
Jan 31, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Gunnar ElkeNorbert Weiler
Mar 1, 1991·DICP : the Annals of Pharmacotherapy·T W Mattox, K M Teasley-Strausburg
Sep 2, 2020·Critical Care : the Official Journal of the Critical Care Forum·Andrew Li, Amartya Mukhopadhyay
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Jul 5, 2018·Intensive Care Medicine·Craig M CoopersmithAndrew Rhodes
Jul 23, 2020·Critical Care Medicine·Clifford S DeutschmanUNKNOWN Research Committee of the Surviving Sepsis Campaign
Jul 18, 2020·Intensive Care Medicine Experimental·Clifford S DeutschmanUNKNOWN Research Committee of the Surviving Sepsis Campaign
May 8, 1998·Computers and Biomedical Research, an International Journal·I GiovanniniG Nuzzo
May 31, 2002·Journal of Pediatric Surgery·Agostino Pierro
Oct 19, 1992·The Medical Journal of Australia·R Bellomo, G Parkin
Dec 1, 1992·Disease-a-month : DM·F B Cerra

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