PMID: 8327280Mar 1, 1993Paper

Respiratory resistance and transcutaneous PO2 during histamine provocation in children with bronchial asthma

Pediatric Pulmonology
D HolmgrenN Aberg

Abstract

Bronchial reactivity was assessed in 66 children with bronchial asthma (aged 8-15 years) by provocation with histamine-HCl during a symptom-free period. A significant bronchial reaction to histamine was defined as a 50% increase in the resistance of the respiratory system (Rrs) determined by the forced oscillation technique. The provocative dose causing a 50% increase in the Rrs (PD50Rrs) was interpolated from the log dose-response curve. The mean PD50Rrs was significantly lower in children with asthma (0.22 mg/mL) compared with a group of healthy children in the same age range (1.55 mg/mL) (P < 0.001). In children with clinically severe asthma, the mean PD50Rrs was lower (0.13 mg/mL) than in children with mild asthma (0.34 mg/mL) (P < 0.001). Transcutaneous PO2 (PtcO2) was monitored in 25 of the children with asthma. In this group the proportion of mild and severe asthma, the baseline lung function variables, and the PD50Rrs were not significantly different from those of the whole group of children. During the reaction, the PtcO2 fell on average by 29% of the baseline value (P < 0.001); in 88% of the children, the fall in PtcO2 was 20% or more of the baseline value. We conclude that histamine provocation tests using the forced...Continue Reading

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Citations

Apr 1, 1997·Acta Paediatrica·G WennergrenS Redfors
Jun 5, 2007·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonAmerican Thoracic Society/European Respiratory Society Working Group on Infant and Young Children Pulmonary Function Testing
Jan 19, 2016·Paediatric Respiratory Reviews·Eleni SkylogianniSotirios Fouzas
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Oct 13, 2016·ERJ Open Research·Nicole Beydon, Iulia Marian

Related Concepts

Airway Resistance
Asthma
Transcutaneous Partial Pressure of Carbon Dioxide Result
Bronchial Provocation Tests
Ceplene
Hydrogen Chloride
Oscillometry
Respiratory Function Tests
Severity of Illness Index
Bronchial Hyperreactivity

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