Respiratory resistance in the emergency department: a reproducible and responsive measure of asthma severity

Chest
Francine M Ducharme, G Michael Davis

Abstract

To determine, in preschool children with an acute asthma exacerbation, the responsiveness to change of respiratory resistance measurements obtained by the forced oscillation (Rfo) technique, and to identify the magnitude of change indicative of airway obstruction reversibility. A prospective observational study of 114 children, aged 3 to 17 years, untrained in the Rfo technique and treated for acute asthma in a tertiary-care pediatric emergency department (ED). A physical examination followed by three measurements of respiratory resistance by forced oscillation were obtained at 8 Hz (Rfo8) and at 16 Hz (Rfo16). In cooperative children, routine spirometry that included FEV1 was also performed on the Custo Vit R (Custo Med; Munich, Germany). All measurements were obtained twice during the course of the ED treatment, before and after treatment with nebulized bronchodilators. The Rfo8 and Rfo16 measurements were highly reproducible (reproducibility coefficients >0.85). Both the Rfo8 and Rfo16 were at least as responsive to change (responsiveness coefficients of 2.3 and 1.2, respectively) as was FEV1 (2.0) and the four clinical signs most sensitive to change (0.6 to 1.0). A 19% change in Rfo8 was suggestive of significant reversibil...Continue Reading

Citations

Oct 10, 2001·The Korean Journal of Internal Medicine·C W KimC S Hong
Nov 13, 2004·Physiological Measurement·François MarchalRené Peslin
Jun 5, 2007·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonUNKNOWN American Thoracic Society/European Respiratory Society Working Group on Infant and Young Children Pulmonary Function Testing
Jan 31, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jennifer L Goralski, Stephanie D Davis
Oct 5, 2017·Expert Review of Respiratory Medicine·Antonio José Justicia-GrandeFederico Martinón-Torres
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·D VilozniH Blau
Nov 20, 2001·Medical & Biological Engineering & Computing·D MacLeod, M Birch
Mar 23, 2010·Pediatric Pulmonology·Lan T T VuFrançois Marchal
Mar 22, 2019·ERJ Open Research·Francine M DucharmeBenjamin Vinet
Aug 12, 2005·Journal of Occupational and Environmental Medicine·Alexis DescathaFrédéric Lofaso
Jan 23, 2018·World Journal of Methodology·Afaf AlblooshiGraham Hall
Jan 31, 2018·Current Allergy and Asthma Reports·Mohammed F ZaidanAlexander Duarte
Feb 5, 2021·Journal of Applied Physiology·Lennart K A LundbladFrancine M Ducharme
Apr 6, 2021·ERJ Open Research·Eero LauhkonenRichard Iles
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Gary L LarsenWayne Morgan

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