PMID: 42038Sep 1, 1979

Respiratory response to hypoxia and hypercapnia after elimination of central chemosensitivity

Pflügers Archiv : European journal of physiology
M E SchlaefkeH H LOESCHCKE

Abstract

Central respiratory drive responding to pH changes was eliminated by bilateral coagulation or cold block of area S (intermediate area) on the ventral medullary surface in 7 anaesthetized cats. Arterial pH, PCO2, and PO2 (4 cats) and the respiratory response to hypoxia and hypercapnia (6 cats) were observed before and after coagulation. After coagulation in hyperoxia the arterial pH dropped from 7.30 to 7.09, the arterial PCO2 was elevated from 4.80 kPa to 8.17 kPa (6 cats). Ventilation increased by 477 ml at a PCO2a of 6.58 kPa when PO2a was reduced from 39.5 kPa to 8.5 kPa before coagulation, after coagulation ventilation increased by 241 ml (4 cats). The peripheral chemoreceptors guaranteed spontaneous breathing even in hyperoxia. The data reveal that the loss of respiratory homeostasis by elimination of the S areas is due to the loss of central chemosensitive drive with concomitant reduction of peripheral chemoreceptor effect.

References

Jul 1, 1978·The Biochemical Journal·J K FrenchR W Carrell
Jan 31, 1979·Pflügers Archiv : European journal of physiology·M E SchlaefkeH H LOESCHCKE
Sep 1, 1979·Pflügers Archiv : European journal of physiology·H H LOESCHCKEA Herker-See
Sep 1, 1975·The Journal of Physiology·J LipskiK M Spyer
Feb 1, 1968·The American Journal of Physiology·W E Crill, D J Reis
Dec 1, 1952·The Journal of Physiology·C VON EULER, U SODERBERG
Feb 1, 1961·The Journal of Comparative Neurology·E TABER
Jun 24, 1963·Annals of the New York Academy of Sciences·H H LOESCHCKEA KONIG
Jun 1, 1964·The Journal of Comparative Neurology·M K COTTLE
May 1, 1946·Journal of Neurophysiology·R S ALEXANDER

Citations

Sep 1, 1979·Pflügers Archiv : European journal of physiology·H H LOESCHCKEA Herker-See
Jul 1, 1982·Respiration Physiology·D E MillhornT G Waldrop
Jun 1, 1994·Respiration Physiology·R J MartinM A Haxhiu
Dec 12, 2001·Respiration Physiology·Y OkadaS Kuwana
Jul 27, 1999·Respiration Physiology·J Milerad, H W Sundell
Jan 16, 2010·Journal of Applied Physiology·H V Forster, Curtis A Smith
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·N S CherniackE M Adams
Apr 28, 2010·The Journal of Physiology·Gregory M BlainJerome A Dempsey
Nov 22, 2011·Respiratory Physiology & Neurobiology·Z CuiJ Duffin
Aug 1, 1997·The Journal of Surgical Research·C J ShanleyR H Bartlett
Apr 21, 2019·Physiological Reports·Candace N RecenoLara R DeRuisseau
Nov 12, 1998·Pediatric Pulmonology·D Gozal
Sep 23, 2020·Communications Biology·Joseph van de WielNicholas Dale

Related Concepts

Anoxemia
Blood
Carbon Dioxide
Felis catus
Chemoreceptor Cells
Denervation
Hydrogen-Ion Concentration
Hypercapnia
Medulla Oblongata
Dioxygen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.