PMID: 8594032Nov 1, 1995Paper

Respiratory response to positive inspiratory pressure in the cat: effects of CO2 and vagal integrity

Journal of Applied Physiology
H Shams, P Scheid

Abstract

Effects of inspiratory pressure support (IPS) on respiration and activity of inspiratory muscles were tested in eight anesthetized cats by recording the diaphragmatic electromyogram (EMGdi) and respiratory variables at four levels of positive inspiratory airway pressure (5, 10, 15, and 20 cmH2O); onset of IPS was triggered by the inspiratory effort of the animal. When IPS was applied with room air (IPSAir) the respiratory frequency (f) was reduced compared with spontaneous breathing and the tidal volume (VT) was significantly increased, which resulted in a fall of arterial PCO2 (PaCO2) at IPS airway pressures (Paw) above 5 cmH2O. Despite this increase in VT, the amplitude of the integrated EMGdi (Adi) was reduced during IPS at all levels of Paw. When arterial hypocapnia is corrected by addition of CO2 to the inspirate, the values of VT at any given Paw were virtually identical with those during IPSAir, but IPS-mediated changes in f and Adi were smaller than those during IPSAir. IPS was also performed after bilateral vagotomy. Vagotomy itself caused VT and Adi to increase, and f to decrease, during spontaneous breathing. In comparison with the corresponding treatment before vagotomy, IPSAir led to a less severe reduction in Adi....Continue Reading

Citations

Sep 2, 2015·American Journal of Respiratory and Critical Care Medicine·Hadrien RozéLaurent Brochard
Dec 8, 1998·Journal of Applied Physiology·B FaurouxF Lofaso
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·J P VialeG Annat

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