PMID: 6431627Jul 1, 1984

Respiratory responses of diabetics to hypoxia, hypercapnia, and exercise

Thorax
J G WilliamsC M OGILVIE

Abstract

The respiratory responses of 52 diabetics and 65 non-diabetic controls to hypoxia, hypercapnia, and exercise were studied. Twenty five per cent of the diabetics had evidence of impaired sensitivity to hypoxia or decreased ventilatory response to hypercapnia, while 7% of the diabetics who performed the exercise tests had an abnormal pattern of respiration during exercise; 33% of the diabetics who performed all three tests of respiratory reflex action had at least one abnormal test response. There was no correlation between the presence of an abnormal respiratory response and the presence of clinical diabetic complications. Abnormal respiratory reflexes could not be predicted from the results of the "routine" pulmonary function tests. The possibility that the abnormal respiratory responses were due to autonomic neuropathy is discussed.

References

Aug 1, 1996·Muscle & Nerve·X NavarroD E Sutherland
Oct 23, 2012·Der Anaesthesist·G PestelM M Weber
Oct 1, 1985·British Journal of Diseases of the Chest·W J Kinnear, J M Shneerson
Jul 1, 1992·Respiration Physiology·H L ManningR M Schwartzstein
Jul 10, 2007·Diabetes Technology & Therapeutics·Connie C W Hsia, Philip Raskin
Jun 7, 2013·Lung India : Official Organ of Indian Chest Society·Swati H ShahSundeep Salvi
Jul 1, 1989·Mayo Clinic Proceedings·L A HansenT V Colby
May 2, 2015·Journal of Physical Therapy Science·Orathai TunkamnerdthaiNaruemon Leelayuwat
Jun 1, 2007·Sleep Medicine Clinics·R Nisha Aurora, Naresh M Punjabi
Aug 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·O L KleinL J Smith
Aug 18, 2004·Life Sciences·Dale R Bergren, Marc S Rendell
Mar 5, 2005·The American Journal of Medicine·Connie C W Hsia, Philip Raskin
Jul 5, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jacqueline K LimbergMichael J Joyner
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J A ClarkeE M Hennessy
Jun 27, 2020·Diabetes/metabolism Research and Reviews·Yue ZhouYangang Wang
Feb 22, 2001·Journal of Applied Physiology·C TantucciG Casucci
Feb 17, 2017·Aging and Disease·Hong ZhengLiang-Jun Yan
Oct 29, 1998·Medizinische Klinik·M J HilzB Neundörfer

Citations

Jan 7, 1978·Lancet·M M Page, P J Watkins
Jul 1, 1977·British Journal of Diseases of the Chest·S G Spiro
Nov 1, 1978·Clinical Science and Molecular Medicine·J M PatrickS B Pearson
Jun 1, 1975·Journal of Applied Physiology·C A HirshmanJ V Weil
Jul 1, 1972·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·G J MillerA Ashworth
Aug 1, 1973·Journal of Applied Physiology·A S RebuckE J Campbell
Apr 11, 1974·The New England Journal of Medicine·J T DavidsonR Lugliani
Oct 1, 1970·Journal of Applied Physiology·E A PhillipsonJ A Nadel
Mar 6, 1971·British Medical Journal·R J EvansD T Hughes
Nov 1, 1981·Clinical Science·I HommaM Abé
Jul 1, 1982·Clinical Science·P M CalverleyD C Flenley
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Jan 1, 1963·Journal of Applied Physiology·E AGOSTONI
Jan 1, 1949·The Journal of Clinical Investigation·G R Meneely, N L Kaltreider
Mar 1, 1948·The American Journal of Physiology·A B OTISW O FENN

Related Concepts

Examination of Reflexes
Dioxygen
Cell Respiration
Exercise Stress Test
Hypercapnia
Pulmonary Function Tests
Respiratory Gaseous Exchange in Organisms
Hypoxia
Respiration
Carbon Dioxide

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.