PMID: 11605929Oct 19, 2001Paper

Respiratory sites of action of propofol: absence of depression of peripheral chemoreflex loop by low-dose propofol

Anesthesiology
D NieuwenhuijsA Dahan

Abstract

Propofol has a depressant effect on metabolic ventilatory control, causing depression of the ventilatory response to acute isocapnic hypoxia, a response mediated via the peripheral chemoreflex loop. In this study, the authors examined the effect of sedative concentrations of propofol on the dynamic ventilatory response to carbon dioxide to obtain information about the respiratory sites of action of propofol. In 10 healthy volunteers, the end-tidal carbon dioxide concentration was varied according to a multifrequency binary sequence that involved 13 steps into and 13 steps out of hypercapnia (total duration, 1,408 s). In each subject, two control studies, two studies at a plasma target propofol concentration of 0.75 microg/ml (P(low)), and two studies at a target propofol concentration of 1.5 microg/ml (P(high)) were performed. The ventilatory responses were separated into a fast peripheral component and a slow central component, characterized by a time constant, carbon dioxide sensitivity, and apneic threshold. Values are mean +/- SD. Plasma propofol concentrations were approximately 0.5 microg/ml for P(low) and approximately 1.3 mg/ml for P(high), Propofol reduced the central carbon dioxide sensitivity from 1.5 +/- 0.4 to 1.2 ...Continue Reading

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Citations

Jun 26, 2004·Clinical Pharmacokinetics·Bart-Jan LichtenbeltJaap Vuyk
May 13, 2009·Current Opinion in Anaesthesiology·John Mark AnserminoMaryam Dosani
Dec 25, 2004·Anesthesiology·Malin M JonssonLars I Eriksson
Mar 20, 2010·Respiratory Physiology & Neurobiology·Maria KlimathianakiDimitris Georgopoulos
Dec 7, 2007·Respiratory Physiology & Neurobiology·Shingi AkadaLars I Eriksson
Oct 9, 2007·Journal of Pharmacological and Toxicological Methods·Simon AuthierEric Troncy
Jan 18, 2006·Veterinary Anaesthesia and Analgesia·Peter J PascoeKaren J Frischmeyer
Dec 30, 2009·Respiratory Physiology & Neurobiology·M CarevZ Dogas
Jul 19, 2018·Clinical Pharmacokinetics·Marko M SahinovicAnthony R Absalom
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Sep 22, 2019·International Journal of Environmental Research and Public Health·Ryuma UrahamaHisahiro Matsubara
Oct 15, 2019·Journal of Pain & Palliative Care Pharmacotherapy·John Bodnar
May 12, 2018·Anesthesiology·Katarina Jennifer RuscicMatthias Eikermann
Feb 3, 2020·Journal of Clinical Monitoring and Computing·Binghao ZhangTimothy C Y Chan
Jan 12, 2020·Anaesthesia Critical Care & Pain Medicine·Benoît PlaudBertrand Debaene

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