Respiratory Support in COVID-19 Patients, with a Focus on Resource-Limited Settings.

The American Journal of Tropical Medicine and Hygiene
Arjen M DondorpMarcus J Schultz

Abstract

The ongoing novel coronavirus disease (COVID-19) pandemic is threatening the global human population, including in countries with resource-limited health facilities. Severe bilateral pneumonia is the main feature of severe COVID-19, and adequate ventilatory support is crucial for patient survival. Although our knowledge of the disease is still rapidly increasing, this review summarizes current guidance on the best provision of ventilatory support, with a focus on resource-limited settings. Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settings where capacity for invasive ventilation is limited. Oxygen delivery can be increased by using a non-rebreathing mask and prone positioning. The presence of only hypoxemia should in general not trigger intubation because hypoxemia is often remarkably well tolerated. Patients with fatigue and at risk for exhaustion, because of respiratory distress, will require invasive ventilation. In these patients, lung protective ventilation is essential. Severe pneumonia in COVID-19 differs in some important aspects from other causes of severe pneumonia or acute respi...Continue Reading

References

May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 22, 2013·The New England Journal of Medicine·Claude GuérinUNKNOWN PROSEVA Study Group
Nov 29, 2013·The New England Journal of Medicine·Arthur S Slutsky, V Marco Ranieri
Feb 18, 2014·American Journal of Respiratory and Critical Care Medicine·Richard K AlbertUNKNOWN Proseva Investigators
Sep 10, 2015·American Journal of Respiratory and Critical Care Medicine·Elisabeth D RivielloRobert A Fowler
Jul 10, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·B D BradleyS R C Howie
Jul 13, 2016·Chest·Eric L ScholtenAtul Malhotra
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Mar 3, 2017·Critical Care Medicine·Jesús VillarUNKNOWN Spanish Initiative for Epidemiology, Stratification and Therapies for ARDS (SIESTA) Investigators Network
May 2, 2017·American Journal of Respiratory and Critical Care Medicine·Eddy FanUNKNOWN American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine
Oct 27, 2017·Annals of the American Thoracic Society·Laveena MunshiEddy Fan
Jan 26, 2018·Intensive Care Medicine·Veronica VercesiUNKNOWN Lung Ultrasound Consortium
Dec 12, 2018·Current Opinion in Critical Care·Rebecca InglisMarcus J Schultz
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Mar 3, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sufang TianShu-Yuan Xiao
Mar 7, 2020·AJR. American Journal of Roentgenology·Shuchang ZhouLiming Xia
Mar 15, 2020·The Lancet. Respiratory Medicine·Rodgers R AyebareMohammed Lamorde
Mar 17, 2020·AJR. American Journal of Roentgenology·Sana SalehiAli Gholamrezanezhad
Mar 20, 2020·JAMA : the Journal of the American Medical Association·Matt ArentzMelissa Lee
Apr 1, 2020·The Lancet Infectious Diseases·Francois-Xavier LescureYazdan Yazdanpanah
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 3, 2020·Frontiers of Medicine·Min ZhouJieming Qu
Apr 3, 2020·The Lancet Infectious Diseases·Robert VerityNeil M Ferguson
Apr 10, 2020·The Lancet. Respiratory Medicine·Jason PhuaUNKNOWN Asian Critical Care Clinical Trials Group

❮ Previous
Next ❯

Citations

May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Ranistha RatanaratMarcus J Schultz
Jul 20, 2020·The American Journal of Tropical Medicine and Hygiene·Rita de Cássia Menezes SoaresLetícia Martins Raposo
Jul 30, 2020·Respiratory Research·Sebastiaan DhontBart N Lambrecht
Sep 16, 2020·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Vinciya PandianMichael J Brenner
Jul 4, 2020·The American Journal of Tropical Medicine and Hygiene·Laura McArthurCharles A Narh
May 27, 2020·Critical Care Medicine·Sara C AuldUNKNOWN and the Emory COVID-19 Quality and Clinical Research Collaborative
Jun 17, 2020·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Matthew B GossAbbas Rana
Jun 15, 2020·Pharmaceutical Medicine·Shubham Atal, Zeenat Fatima
Oct 13, 2020·Frontiers in Pharmacology·Chandan SarkarDaniela Calina
Sep 26, 2020·Journal of Medical Internet Research·Patrick SchwabStefan Bauer
Oct 17, 2020·SN Computer Science·Md Milon IslamS M Taslim Uddin Raju
Sep 18, 2020·The American Journal of Tropical Medicine and Hygiene·Yuki Otsuka, Taiichiro Kobayashi
Nov 26, 2020·Journal of Intensive Care Medicine·Rajiv SontiNathan Cobb
Jan 14, 2021·Revista latino-americana de enfermagem·Marília Souto de AraújoSoraya Maria de Medeiros
Jan 13, 2021·The American Journal of Tropical Medicine and Hygiene·Philip J Rosenthal
Oct 29, 2020·Journal of Global Health·Amita Sudhir, Nachiket Mor
Nov 21, 2020·Journal of Global Health·Devasahayam J ChristopherBalamugesh Thangakunam
Jan 15, 2021·Clinical Interventions in Aging·Bogna Grygiel-Górniak, Mary-Tiffany Oduah
Feb 8, 2021·The American Journal of Emergency Medicine·Stephanie CardonaQuincy K Tran
Feb 9, 2021·Frontiers in Medicine·Victoria TeamCarolina D Weller
Nov 14, 2020·Intensive Care Medicine·Jorge I F SalluhRashan Haniffa
Feb 10, 2021·Scientific Reports·Fernando Timoteo FernandesAlexandre Dias Porto Chiavegatto Filho
Mar 6, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Iffat KhanumJamil Bushra
Apr 26, 2020·The American Journal of Tropical Medicine and Hygiene·Marcus J SchultzArjen M Dondorp
Mar 2, 2021·Respiratory Medicine Case Reports·Michael F HarrisonDevang K Sanghavi
Dec 1, 2020·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Kevin RoedlStefan Kluge
Mar 21, 2021·Journal of Infection and Public Health·Chen-Yang HsuHsiu-His Chen
Apr 15, 2021·Intensive Care Medicine·Pedro KurtzFernando A Bozza
Apr 27, 2021·Journal of Manufacturing Systems·Md Sarower TareqPeter Dorrington
May 1, 2021·Journal of Clinical Medicine·Krešimir PavelićNandu Goswami
May 8, 2021·Dimensions of Critical Care Nursing : DCCN·Julianne M EversMichelle G Urquhart
May 16, 2021·Tropical Medicine and Health·Nelson Ashinedu UkorDon Eliseo Lucero-Prisno
Apr 25, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Eric Arnaud DiendéréSéni Kouanda
Jul 1, 2021·Respiratory Medicine Case Reports·Ryuichi NakayamaEichi Narimatsu
Jun 28, 2021·The American Journal of Emergency Medicine·Jessica DowningQuincy K Tran
Jun 20, 2021·Patient Education and Counseling·Rachael L Spalding, Barry Edelstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
Paolo Maria LeoneLuca Richeldi
American Journal of Respiratory and Critical Care Medicine
Pradeep Bhatia, Sadik Mohammed
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Sadaf Sheikh, Muhammad Akbar Baig
Critical Care : the Official Journal of the Critical Care Forum
Wen Ting SiowKay Choong See
© 2022 Meta ULC. All rights reserved