PMID: 22335500Feb 18, 2012Paper

Respiratory syncytial virus infection in adult populations

Infectious Disorders Drug Targets
E E Walsh, Ann R Falsey

Abstract

Respiratory Syncytial Virus, generally recognized for its role as the major respiratory pathogen in newborn infants and young children, is also a significant pathogen in adults. It is a frequent cause of upper and lower respiratory illness among all age groups, although it often goes unrecognized in adults unless highly sensitive molecular diagnostic tests are used. All RSV infections in adults represent re-infection and are generally mild to moderate in severity, although persons with certain high-risk conditions are susceptible to severe disease. These include the frail elderly living at home or in long term care facilities, those with underlying chronic pulmonary disease, and the severely immunocompromised. It is estimated that between 11,000-17,000 adults die of RSV infection annually in the U.S, with ~ ten-fold more admitted to hospital with respiratory symptoms. As in infants, wheezing is often noted during RSV infections and chest radiographs are often normal despite significant lower respiratory symptoms and hypoxia. Treatment of RSV is directed at symptomatic relief, and only rarely is specific antiviral therapy recommended. Exceptions include the severely immunocompromised, in whom inhaled ribavirin has been recommend...Continue Reading

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