Respiratory syncytial virus serology by a simplified enzyme-linked immunosorbent assay.

Journal of Clinical Microbiology
M C SteinhoffK C Schnabel

Abstract

A simplified enzyme-linked immunosorbent assay (ELISA) which utilized commercially available reagents was developed for respiratory syncytial virus (RSV)-specific immunoglobulin G. An analysis of the inherent variation of the assay allowed the setting of strict criteria for determining a significant change in RSV antibodies. The ELISA was more sensitive than the standard complement fixation or microneutralization tests in a carefully studied group of 32 RSV-infected adults. The ELISA correlated closely with complement fixation serological testing in 25 patients. The use of purified antigens might allow the development of a more sensitive ELISA.

References

Oct 1, 1977·The Journal of Infectious Diseases·P O Leinikki, S Passila

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Citations

Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johanna Nokso-KoivistoTapani Hovi
Sep 24, 2013·Expert Review of Vaccines·Vanessa KurzweilMark T Esser

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