Respiratory Syncytial Virus Vaccine Approaches: a Current Overview

Current Clinical Microbiology Reports
Carolyn M Clark, Antonieta Guerrero-Plata

Abstract

Respiratory syncytial virus (RSV) is a global human pathogen responsible for lower respiratory tract infections (LRTI). While RSV infection is innocuous in healthy adults, it is the leading cause of infant hospitalization for respiratory tract infection. Nearly everyone shows evidence of an RSV infection by the age of 3. However, there is still not a vaccine commercially available. This review will provide an update on the clinical and preclinical vaccine studies and different approaches to prevent RSV infection. Novel vaccine approaches that induce protection against RSV without enhancement of respiratory tract disease. Recent technological approaches have led to generation of different strategies to prevent RSV infection, including live attenuated, chimeric, and subunit vaccines, virus-like particles, and nanoparticles. These vaccine approaches represent promising candidates towards an efficient RSV vaccine that effectively protects infants, children, and adults.

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Citations

Apr 9, 2020·Expert Opinion on Biological Therapy·Seyhan Boyoglu-Barnum, Ralph A Tripp
Sep 11, 2019·Vaccines·Ralph A Tripp, Ultan F Power
Apr 29, 2020·The Journal of Allergy and Clinical Immunology·Andrew W LindsleyMarc E Rothenberg
Jun 17, 2020·International Archives of Allergy and Immunology·Hans-Uwe SimonMartin F Bachmann

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