Jun 7, 2014

Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations

Journal of Leukocyte Biology
Rakesh K KumarH F Rosenberg

Abstract

Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP, as well as their targets, type 2 innate lymphoid cells (ILC2s), in the pathogenesis of virus-induced asthma exacerbations. Production and release of these cytokines lead to recruitment and activation of ILC2s, which secrete mediators, including IL-5 and IL-13, which augment allergic inflammation. However, little information is currently available about the induction of these responses by the respiratory viruses that are strongly associated with exacerbations of asthma, such as rhinoviruses. Further human studies, as well as improved animal experimental models, are needed to investigate appropriately the pathogenetic mechanisms in virus-induced exacerbations of asthma, including the role of ILCs.

  • References85
  • Citations28

References

Mentioned in this Paper

TSLP protein, human
Picornaviridae Infections
Respiratory Syncytial Virus Infections
Interleukins
Pathogenic Aspects
C19orf10 gene
Pathogenesis
Respiratory Tract Structure
Virus Diseases
Recombinant Interleukin-5

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.