Respiratory viral infections are underdiagnosed in patients with suspected sepsis

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
L R LjungströmH Enroth

Abstract

The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season. During 11 weeks of the influenza epidemic period in January-March 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex PCR for respiratory viruses on the nasopharyngeal specimen. The results were compared with those from microbiology analyses ordered as part of standard care. During the winter season, viral respiratory pathogens, mainly influenza A virus, human metapneumovirus, coronavirus, and respiratory syncytial virus were clinically underdiagnosed in 70% of patients positive by the multiplex PCR assay. During the first four weeks of the influenza epidemic, few tests for influenza were ordered by clinicians, indicating low awareness that the epidemic had started. Nasopharyngeal findings of Streptococcus pneumoniae and Haemophilus influenzae by culture correlated to pneumonia diagnosis, and in those patients laboratory signs of viral co-infections were common but rarely suspected by clinicians. The role of respiratory viral infections in patients presenting with a c...Continue Reading

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Citations

May 23, 2019·The Journal of Infectious Diseases·Catia CillónizAntoni Torres
Jul 9, 2020·Oral Diseases·Maria Stella MoreiraRicardo Simões Neves
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Aug 25, 2020·Critical Care Medicine·Claire N ShappellChanu Rhee
Jan 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Le NingYinchuan Xu
Jul 3, 2019·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kyoung Hwa LeeYong Goo Song

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Methods Mentioned

BETA
PCR
X-ray

Software Mentioned

Seegene viewer
Respifinder
Pathofinder
Seegene

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