Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment

European Respiratory Review : an Official Journal of the European Respiratory Society
Xiaoying GuBin Cao

Abstract

According to the Third International Consensus Definition for Sepsis and Septic Shock, sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Epidemiological data about sepsis from the 2017 Global Burden of Diseases, Injuries and Risk Factor Study showed that the global burden of sepsis was greater than previously estimated. Bacteria have been shown to be the predominant pathogen of sepsis among patients with pathogens detected, while sepsis caused by viruses is underdiagnosed worldwide. The coronavirus disease that emerged in 2019 in China and now in many other countries has brought viral sepsis back into the vision of physicians and researchers worldwide. Although the current understanding of the pathophysiology of sepsis has improved, the differences between viral and bacterial sepsis at the level of pathophysiology are not well understood. Diagnosis methods that can broadly differentiate between bacterial and viral sepsis at the initial stage after the development of sepsis are limited. New treatments that can be applied at clinics for sepsis are scarce and this situation is not consistent with the growing understanding of pathophysiology. This review aims to give a brief sum...Continue Reading

References

Sep 1, 1990·Infection and Immunity·C L Nickerson, G J Jakab
Nov 27, 1999·FEMS Immunology and Medical Microbiology·J M HamentT F Wolfs
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard S HotchkissIrene E Karl
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Louis VincentMarc-Jacques Dubois
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Jul 10, 2003·JAMA : the Journal of the American Medical Association·Edward AbrahamUNKNOWN OPTIMIST Trial Study Group
Jul 16, 2003·Annals of Internal Medicine·George ZahariadisLawrence Corey
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Apr 7, 2004·The Journal of Infection·Ai Ping Chua, Kang Hoe Lee
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Dec 21, 2004·The Journal of Infectious Diseases·Gabriella A FarcasKevin C Kain
Jan 21, 2006·Critical Care Medicine·Jean-Louis VincentUNKNOWN Sepsis Occurrence in Acutely Ill Patients Investigators
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Jun 8, 2007·Emerging Infectious Diseases·Mongkol UiprasertkulPrasert Auewarakul
Oct 2, 2007·Lancet·Wai Fu Ng, Ka Fai To
Aug 12, 2008·Current Pharmaceutical Design·Katherine E Hodgin, Marc Moss
Dec 17, 2008·Annals of the New York Academy of Sciences·Taro Kawai, Shizuo Akira
Mar 26, 2009·The New England Journal of Medicine·Simon FinferJuan J Ronco
May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
Jul 1, 2009·The New England Journal of Medicine·Rogelio Perez-PadillaUNKNOWN INER Working Group on Influenza
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Feb 9, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin K W ToKwok-Yung Yuen
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Mar 23, 2010·Archives of Medical Research·Jeannette Guarner, Reynaldo Falcón-Escobedo
Apr 29, 2010·The Journal of Infectious Diseases·Michael G IsonFrederick G Hayden
Oct 13, 2010·Annual Review of Pathology·Michael A Matthay, Rachel L Zemans
Jan 20, 2011·The Journal of Biological Chemistry·Tie Fu LiuCharles E McCall
Mar 3, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alexandra HeiningerKlaus Hamprecht
Mar 26, 2011·Lancet·Olli RuuskanenDavid R Murdoch
Apr 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David N Gilbert
Aug 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ke HanGuang Zeng

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