Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

Frontiers in Microbiology
Leon CalyDavid A Jans

Abstract

The respiratory diseases caused by rhinovirus, respiratory syncytial virus, and influenza virus represent a large social and financial burden on healthcare worldwide. Although all three viruses have distinctly unique properties in terms of infection and replication, they share the ability to exploit/manipulate the host-cell nucleocytoplasmic transport system in order to replicate effectively and efficiently. This review outlines the various ways in which infection by these viruses impacts on the host nucleocytoplasmic transport system, and examples where inhibition thereof in turn decreases viral replication. The highly conserved nature of the nucleocytoplasmic transport system and the viral proteins that interact with it make this virus-host interface a prime candidate for the development of specific antiviral therapeutics in the future.

References

Nov 6, 1992·Science·C Dingwall, R Laskey
Mar 10, 1989·Cell·J M GreveA McClelland
Sep 1, 1987·The Journal of General Virology·S LevineP R Paradiso
Aug 1, 1995·The Journal of Infectious Diseases·A R FalseyR F Betts
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·F HoferD Blaas
Oct 16, 1993·BMJ : British Medical Journal·K G NicholsonD C Ireland
Jul 1, 1996·Physiological Reviews·D A Jans, S Hübner
Aug 1, 1996·British Journal of Cancer·E S NewlandsM H Brampton
Aug 1, 1997·The Journal of Infectious Diseases·M LuoW J Brouillette
Nov 26, 1997·Journal of Virology·G NeumannY Kawaoka
Jul 17, 1999·Trends in Cell Biology·B Talcott, M S Moore
Feb 23, 2000·The Journal of Cell Biology·M P RoutB T Chait
Oct 24, 2000·Journal of Virology·L K HallakM E Peeples
Mar 22, 2002·The Journal of General Virology·R GhildyalJ Meanger
Jun 5, 2002·Annual Review of Biochemistry·Sandra L Wolin, Tommy Cedervall
Jul 19, 2002·Reviews in Medical Virology·Arianna LoregianGiorgio Palù
Aug 2, 2002·The Pediatric Infectious Disease Journal·Leonard R Krilov
Nov 1, 2002·Journal of Clinical Microbiology·Soile BlomqvistTapani Hovi
Dec 20, 2002·Nucleic Acids Research·Michiyasu ItohJun-ichi Fujisawa
Jul 30, 2003·The Journal of Cell Biology·Janna BednenkoLarry Gerace
May 15, 1964·Science·W L DAVIESC E HOFFMANN
Feb 26, 2004·Paediatric Respiratory Reviews·Pearay L Ogra
Feb 1, 1996·Trends in Cell Biology·G WhittakerA Helenius
Sep 28, 2004·The Journal of General Virology·S P AminevaJ E Gern
Jan 29, 2005·The Journal of Biological Chemistry·Riku FagerlundKrister Melén
Aug 17, 2006·FEMS Microbiology Reviews·Reena GhildyalDavid A Jans
Jan 27, 2007·The Cochrane Database of Systematic Reviews·K Ventre, A G Randolph
Feb 9, 2007·Nature Reviews. Molecular Cell Biology·Murray Stewart
Feb 24, 2007·Trends in Cell Biology·Saskia Hutten, Ralph H Kehlenbach
Mar 31, 2007·The Journal of Biological Chemistry·John Hiscott
Jun 5, 2007·Vaccine·Noelle-Angelique M MolinariCarolyn B Bridges

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Citations

Mar 23, 2018·Parasitology·Marina A Gwairgi, Reena Ghildyal
Mar 20, 2020·Microbiology and Molecular Biology Reviews : MMBR·Steven M PascalKomala Ponniah
Jun 24, 2017·Annual Review of Virology·Kimi AzadJohn E Johnson

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