Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside

Future Microbiology
Justin BeardsleyTania C Sorrell

Abstract

The incidence of serious fungal infections is increasing rapidly, and yet the rate of new drugs becoming available to treat them is slow. The limited therapeutic armamentarium is a challenge for clinicians, because the available drugs are often toxic, expensive, difficult to administer, ineffective or a combination of all four. Given this setting, the emergence of resistance is especially concerning, and a review of the topic is timely. Here we discuss antifungal drug resistance in Candida spp. and Aspergillus spp. with reference to the most commonly used first-line antifungal agents - azoles and echinocandins. We review the resistance mechanisms of the leading pathogens, how resistance can be identified in the diagnostic lab and the clinical implications of resistance once detected.

References

Jun 14, 1996·The Journal of Biological Chemistry·P Mazur, W Baginsky
Dec 1, 1996·Antimicrobial Agents and Chemotherapy·G D AlbertsonH F Jenkinson
Jun 1, 1997·Antimicrobial Agents and Chemotherapy·D W DenningS L Kelly
Jun 15, 1997·FEMS Microbiology Letters·J LöfflerH Einsele
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·A S OrozcoS G Filler
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sofia Perea, Thomas F Patterson
Dec 10, 2003·Journal of Clinical Microbiology·Alexander ImhofKieren A Marr
Jun 16, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·David S Perlin
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zeina A Kanafani, John R Perfect
Apr 21, 2009·Applied and Environmental Microbiology·Eveline SneldersPaul E Verweij
Sep 11, 2009·Current Opinion in Infectious Diseases·David S Perlin
Mar 6, 2010·The Journal of Antimicrobial Chemotherapy·Monica A SlavinUNKNOWN Australian Candidemia Study, Australasian Society for Infectious Diseases
Jul 28, 2010·Bone Marrow Transplantation·J MaertensUNKNOWN Third European Conference on Infections in Leukemia
Aug 25, 2010·Antimicrobial Agents and Chemotherapy·Claire M MartelSteven L Kelly
Jul 20, 2011·Antimicrobial Agents and Chemotherapy·Susan J HowardDavid W Denning
Oct 18, 2011·Emerging Infectious Diseases·Jan W M van der LindenPaul E Verweij
Jan 4, 2012·The American Journal of Medicine·Michael A Pfaller
Aug 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela Ahlquist ClevelandTom M Chiller
Dec 12, 2012·The Journal of Antimicrobial Chemotherapy·Cen JiangYibing Peng
Mar 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara D AlexanderMichael A Pfaller
Jan 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Cuenca-Estrella
Jan 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C Arendrup
Mar 13, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Maiken C ArendrupWilliam W Hope
Apr 23, 2014·British Journal of Haematology·Laura Alcazar-Fuoli, Emilia Mellado
May 16, 2014·Journal of Clinical Microbiology·Catiana DudiukGuillermo Garcia-Effron

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Citations

Jul 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·E H TaudorfD M L Saunte
Feb 8, 2020·Expert Review of Molecular Diagnostics·Peter J DaileyMark Holodniy
Mar 4, 2020·Journal of Fungi·Camila BonicheCarlos Pelleschi Taborda
Mar 18, 2020·Metabolites·Jiří HoušťVladimír Havlíček
Jul 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mendel FriedmanKirkwood M Land
Jun 6, 2019·Methods and Protocols·Jong H KimKirkwood M Land
Sep 19, 2019·World Journal of Clinical Cases·Xue-Fei XiaoYang-Cheng Xu
Nov 18, 2019·Current Infectious Disease Reports·Joshua A HendricksonNicholas Beyda
Apr 9, 2020·Frontiers in Microbiology·Afsane VaeziHamid Badali
Jul 24, 2020·Current Fungal Infection Reports·Alison R NovakScott W Mueller
Apr 12, 2019·Frontiers in Microbiology·XinRui XingYingYing Cao
Sep 12, 2020·Environmental Science and Pollution Research International·Hailemariam Abrha AssressTitus A M Msagati
Dec 10, 2020·Computational and Structural Biotechnology Journal·Tanushree TunstallNicholas Furnham
Jan 28, 2021·Journal of Fungi·Jasminka TalapkoIvana Škrlec
Nov 19, 2020·Antibiotics·Jong H KimKirkwood M Land
Feb 2, 2021·Pathology·Arthur J MorrisSally A Roberts
Mar 7, 2021·International Journal of Molecular Sciences·Jakub Suchodolski, Anna Krasowska
Apr 4, 2021·Journal of Fungi·Pascal ArnéJacques Guillot
Apr 4, 2021·Journal of Global Antimicrobial Resistance·Larissa M FavarelloArnaldo L Colombo
Jan 31, 2020·European Journal of Medicinal Chemistry·David MontoirCédric Logé
Feb 24, 2021·Antimicrobial Agents and Chemotherapy·Cheryl LeongThomas L Dawson
May 22, 2021·Infectious Disease Clinics of North America·Melissa D Johnson
Jun 17, 2021·The Journal of Dermatological Treatment·Aditya K Gupta, Maanasa Venkataraman
Jun 17, 2021·Infection·Vasiliki SoulountsiSerafeim Chrysovalantis Kotoulas
Aug 12, 2021·JAC-antimicrobial Resistance·Alexander Maximilian AldejohannOliver Kurzai

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Methods Mentioned

BETA
PCR
genotyping
bronchoalveolar lavage

Software Mentioned

Vitek
Etest
YeastOne

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