Response acceleration in post-translationally regulated genetic circuits.

Journal of Molecular Biology
Alexander Y Mitrophanov, Eduardo A Groisman

Abstract

Transcription factors must often be chemically modified to perform their functions. Yet, it is not known whether the mechanisms that bring about such modifications impact the quantitative or kinetic properties of gene expression. Phosphorylation controls the activity of regulatory proteins of the two-component system family, which constitutes a prevalent form of bacterial signal transduction. These proteins are phosphorylated/dephosphorylated by cognate sensor proteins in response to specific signals. The phosphorylation level of the regulatory proteins is also modulated by small proteins-termed connectors-that are produced when a cell experiences signals other than those detected directly by the sensors. Here, we explore how differences in the targets (i.e., sensor or regulator) and the mechanisms used by connectors to generate phosphorylated regulatory proteins affect the output of two-component systems. Our mathematical modeling demonstrates that sensor-targeting mechanisms exhibit stronger response acceleration than those where the connector targets the regulator. These differences are robust to perturbations in kinetic parameters but dependent upon the specific sensor-to-regulator ratio and how the ratio is controlled in l...Continue Reading

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Citations

May 6, 2010·PLoS Computational Biology·Liming WangQing Nie
Sep 10, 2010·Annual Review of Microbiology·Rafael Silva-Rocha, Víctor de Lorenzo
Jul 6, 2010·Journal of Molecular Biology·Alexander Y MitrophanovEduardo A Groisman
Dec 4, 2015·PLoS Computational Biology·Sridevi NagarajaAlexander Y Mitrophanov

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