Response assessment of somatostatin receptor targeted radioligand therapies for progressive intracranial meningioma.

Nuklearmedizin. Nuclear Medicine
Michael MütherKambiz Rahbar

Abstract

 In somatostatin receptor (SSTR) expressing progressive meningioma, peptide receptor radionuclide therapy (PRRT) has shown effect in small clinical series. However, standardized treatment and response assessment protocols are lacking. We present our experience on PPRT with 177Lu-DOTATATE in progressive meningioma with a special emphasis on state-of-the-art response assessment.  Retrospective analysis on PRRT with 177Lu-DOTATATE from 2015 to 2019. Pre- and post-therapy imaging was performed using MRI and 68Ga-DOTATATE-PET for standard bidimensional and volumetric analyses, respectively, following novel RANO guidelines.  Seven patients with progressive intracranial meningioma (median age 73 years, interquartile range 60-76; 5 WHO II, 2 WHO I; 5 multifocal) received a median of 4 cycles 2 3 4 of PRRT with 177Lu-DOTATATE in eight-week intervals. Three patients did not undergo post-therapy 68Ga-DOTATATE-PET due to early symptomatic progression and subsequent cessation of PRRT. After completion of 4 PRRT cycles volumetric PET imaging showed stable disease in two of four patients. According to bidimensional MRI response assessment, only one patient was stable. Progression free survival at six months was 42.9 %.  In this heterogeneous ...Continue Reading

References

Jul 10, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P KrenningR Valkema
Mar 26, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Mirco BartolomeiGiovanni Paganelli
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Feb 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·L BodeiJohn J Zaknun
May 9, 2014·Cancer Biotherapy & Radiopharmaceuticals·Fabio MinutoliSergio Baldari
Dec 3, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardUNKNOWN European Association of Nuclear Medicine (EANM)
Jan 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ezgi IlanMark Lubberink
Jan 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nicolas MarincekMartin A Walter
Jan 22, 2015·Clinical Nuclear Medicine·William MakisAlexander J B McEwan
Jan 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Walter RachingerJörg-Christian Tonn
Aug 22, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Karine Gerster-GilliéronDominik Cordier
Feb 13, 2016·Neuro-oncology·Michael SommerauerFelix P Kuhn
Sep 7, 2016·The Lancet Oncology·Roland GoldbrunnerMichael Weller
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators
Jun 13, 2017·Neuro-oncology·Norbert GalldiksJörg C Tonn
Dec 16, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Eric GuedjDavid Taieb

❮ Previous
Next ❯

Citations

Oct 12, 2021·Current Opinion in Neurology·Thomas GraillonOlivier Chinot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.