Abstract
Characteristic response patterns are described for two antidepressant drugs and placebo in post-traumatic stress disorder. Early onset and steady improvement occurred on a global rating scale for both drugs and placebo in those who ultimately met responder criteria at the end of treatment. In certain cases, the magnitude of global response was greater for drug than for placebo. At weeks 2 or 4, the Clinical Global Impressions score for fluoxetine but not for amitriptyline, served as a good predictor of eventual response. In a review of numerous completed placebo-controlled trials, antidepressants were superior to placebo in seven out of eight comparisons using the Clinical Global Impressions, although specific effects on post-traumatic stress disorder scales were more variable. Drug response rates are similar for combat and civilian trauma samples, but placebo response rates may be higher in the latter. Effect sizes suggested a moderate-to-good effect for drug therapy.
Citations
Aug 31, 2002·Depression and Anxiety·Jonathan R T DavidsonDavid Hackett
Dec 22, 1999·Biological Psychiatry·J C Ballenger
Apr 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·K M ConnorJ R Davidson
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Meera VaswaniSubramanyam Ramesh
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S Montgomery, P Bech
Mar 18, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Iris R BellCarol M Baldwin
Jul 19, 2001·International Clinical Psychopharmacology·M I ButterfieldJ R Davidson
Nov 20, 2001·International Clinical Psychopharmacology·F PettyK A Young
Aug 22, 2008·Croatian Medical Journal·Dragica Kozaric-Kovacic
Oct 2, 2009·Journal of Psychiatric Research·Alessandra A LimaIvan Figueira
May 20, 1999·Biological Psychiatry·M A HertzbergJ R Davidson
Nov 7, 2006·Journal of Psychosomatic Research·Daniella AmitalHoward Amital
Apr 18, 2003·Journal of Traumatic Stress·Elizabeth A Hembree, Edna B Foa
Jun 22, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Judith A CohenVirginia Staron
Jun 23, 1999·Journal of Traumatic Stress·M L MalikJ R Davidson
Nov 29, 2002·Human Psychopharmacology·Michel Bourin, Olivier Lambert
Jan 27, 2006·The Cochrane Database of Systematic Reviews·D J SteinS Seedat
Aug 17, 2000·Depression and Anxiety·R M Hirschfeld
May 20, 2003·Acta Psychiatrica Scandinavica·M JakovljevićA Mihaljević-Peles
Jan 10, 2002·Acta Psychiatrica Scandinavica·I HagemanM B Jørgensen
Dec 18, 2004·Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine·L Sher
Sep 17, 2020·Journal of Clinical Medicine·Gjumrakch AlievCecil E Kirkland