Jul 22, 1998

Response-dose ratio as an index of bronchial responsiveness to hypertonic saline challenge in an epidemiological survey of asthma in Polish children

Pediatric Pulmonology
G Lis, J J Pietrzyk


This epidemiological survey was done to evaluate the bronchial responsiveness (BHR) to a 4.5% hypertonic saline (HS) challenge in 13-14 year-old schoolchildren. BHR was measured by the response-dose ratio in which the response was estimated by the decline of FEV1 index of BHR (IxFEV1). Validity of the HS challenge test as a screening test for confirmation of reported asthma symptoms and the diagnosis of asthma was assessed. With a cutoff of 90th percentile of IxFEV1 in controls, the test sensitivity and specificity for asthma symptoms in the last 12 months was 44% and 90%, respectively. For the diagnosis of asthma the test sensitivity was 67% and specificity 90%. The mean log transform of IxFEV1 was significantly higher in children with more than three episodes of wheezing in the last 12 months and a diagnosis of asthma than in controls. Moreover, in the group with more than three episodes of asthma in the last 12 months the mean IxFEV1 was higher in girls than in boys. There was no gender difference in other groups of asthmatic children and controls. In Polish schoolchildren the prevalence of BHR to HS was 12.5% when adjusted to the prevalence of wheezing in the last 12 months. By multiple linear regression analysis, factors a...Continue Reading

  • References21
  • Citations3


Mentioned in this Paper

Inhalation of Drugs
Muscle Hypertonia
Bronchial Provocation Tests
Logistic Regression
Immunoglobulin E
Saline Solution, Hypertonic
Bronchial Hyperreactivity

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.