Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism

The Journal of Steroid Biochemistry and Molecular Biology
John S AdamsJ Barsony

Abstract

Using vitamin D-resistant New World primates as model of natural diversity for sterol/steroid action and metabolism, two families of novel intracellular vitamin D regulatory proteins have been discovered and their human homologs elucidated. The first family of proteins, heterogeneous nuclear ribonucleoproteins (hnRNPs), initially considered to function only as pre-mRNA-interacting proteins, have been demonstrated to be potent cis-acting, trans-dominant regulators of vitamin D hormone-driven gene transactivation. The second group of proteins bind 25-hydroxylated vitamin D metabolites. Their overexpression increases vitamin D receptor (VDR)-directed target gene expression. We found that these intracellular vitamin D binding proteins (IDBPs) are homologous to proteins in the heat shock protein-70 family. Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting.

References

Mar 1, 1991·The Journal of Clinical Investigation·M A Gacad, J S Adams
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J S Adams, M A Gacad
Mar 1, 1984·Scientific American·D Pilbeam
Apr 1, 1994·Baillière's Clinical Endocrinology and Metabolism·M Hewison, J L O'Riordan
Jan 1, 1993·Annual Review of Biochemistry·G DreyfussC G Burd
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Gacad, J S Adams
Oct 1, 1996·Molecular Endocrinology·K B HorwitzL Tung
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·E I Christensen, T E Willnow
Jun 28, 2001·Physiological Reviews·A Aranda, A Pascual
Jun 5, 2002·Current Opinion in Lipidology·Thomas E Willnow, Anders Nykjaer
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong ChenJohn S Adams
Jan 1, 1992·American Journal of Primatology·Mercedes A GacadJohn S Adams
Jan 1, 1985·American Journal of Primatology·John S AdamsRobert K Rude

❮ Previous
Next ❯

Citations

May 27, 2008·Nature Reviews. Molecular Cell Biology·Suzanne Eaton
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristina EdfeldtRobert L Modlin
Dec 3, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas S LisseMartin Hewison
Jun 3, 2005·Current Opinion in Nephrology and Hypertension·Geoffrey N Hendy, David Goltzman
May 23, 2008·The Journal of Endocrinology·Rene F ChunMartin Hewison
Dec 7, 2007·Biogerontology·Verónica González PardoAna Russo de Boland
Jan 13, 2006·Kidney International·G N HendyD Goltzman
Oct 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Enrico BaroniDaniele D'Ambrosio
Jun 17, 2008·Molecular Aspects of Medicine·Alex J Brown, Eduardo Slatopolsky
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John S AdamsMartin Hewison
Dec 8, 2010·Geriatrics & Gerontology International·Matteo CesariMarco Pahor
Apr 16, 2010·Annals of the New York Academy of Sciences·David Goltzman
Jan 13, 2006·Molecular and Cellular Endocrinology·Regina EbertFranz Jakob
Aug 23, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Roger BouillonAnnemieke Verstuyf
Jul 9, 2005·Trends in Endocrinology and Metabolism : TEM·Ricardo BolandAna Russo De Boland
Oct 7, 2011·Endocrine Research·Ulrich C BangJens-Erik Beck Jensen
Apr 22, 2008·Archives of Biochemistry and Biophysics·René St-Arnaud
Nov 30, 2018·Physiological Research·L MáčováR Hampl
Nov 12, 2019·Frontiers in Endocrinology·Rene F ChunJohn S Adams
Feb 8, 2020·Nature Reviews. Endocrinology·Daniel Bikle, Sylvia Christakos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.