Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.

World Journal of Gastroenterology : WJG
Ramin Schirin-SokhanJens J W Tischendorf

Abstract

To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment (CEUS date 1) and before the second (CEUS date 2) and fourth (CEUS date 3) cycle of bevacizumab based chemotherapy. Three parameters [PEAK, Time to peak (TTP) and RISE RATE]were correlated with radiological response. For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response. Based on these response criteria there was a significant (P < 0.001) correlation in TTP between metastases of responders (9.08 s) and non-responders (14.76 s) archived on CEUS date 1. By calculating a standardized quotient (metastases divided by normal liver tissue) we were able to define a cut off, predicting response with a sensitivity of 92.3 % and a specificity of 100 %. To reflect a palliative intention only those patients with progressive disease were classified as non-responders. In this stetting TTP was also significantly (P < 0.01) different between responders and non-respond...Continue Reading

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Citations

Jan 17, 2013·World Journal of Gastroenterology : WJG·Jian AngLi Chen
Feb 23, 2013·World Journal of Gastroenterology : WJG·Francois GhiringhelliSylvain Ladoire
Sep 16, 2014·Imaging in Medicine·Reshu Saini, Kenneth Hoyt
Dec 18, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Livia BernardinNandita M Desouza
Jun 28, 2015·Ultrasound in Medicine & Biology·Kenneth HoytAndres Forero-Torres
Dec 9, 2017·AJR. American Journal of Roentgenology·Emily H T PangAlison C Harris

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