Response-guided therapy for patients with hepatitis C virus genotype 6 infection: a pilot study

Journal of Viral Hepatitis
P TangkijvanichY Poovorawan

Abstract

The optimal duration of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RBV) in patients with hepatitis C virus (HCV) genotype 6 is unknown. This study was aimed at determining treatment response on the basis of rapid virological response (RVR) of HCV genotype 6 in comparison with genotypes 1 and 3. Sixty-six treatment naïve patients were treated with PEG-IFN-α2a (180 μg/week) plus weight-based RBV (1000-1200 mg/day). Patients with genotype 1 n = 16) and genotype 3 (n = 16) were treated for a fixed duration of 48 and 24 weeks, respectively. Patients with genotype 6 (n = 34) who achieved RVR were treated for 24 weeks (response-guided therapy) and the remaining patients were treated for 48 weeks (standard therapy). The mean baseline HCV RNA levels were not statistically different between groups (6.4 ± 0.8, 6.0 ± 1.0 and 6.5 ± 0.8 Log(10) IU/mL for genotypes 1, 3 and 6, respectively). Patients with genotypes 1, 3 and 6 achieved RVR in 43.8%, 87.5% and 73.5% of cases, respectively. One patient with genotype 1 and 3 with genotype 6 were considered nonresponders and discontinued therapy. Sustained virological response (SVR) was achieved in 62.5%, 81.3% and 76.5% of patients with genotypes 1, 3 and 6, respectively. The S...Continue Reading

References

Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anouk T DevWilliam Sievert
Mar 28, 2003·The Journal of Infectious Diseases·Chee-Kin HuiChing-Lung Lai
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donald M JensenBernard Willems
Jul 13, 2007·The New England Journal of Medicine·Mitchell L ShiffmanUNKNOWN ACCELERATE Investigators
Nov 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardUNKNOWN North-C Group
May 28, 2008·Gastroenterology·Peter FerenciUNKNOWN Austrian Hepatitis Study Group
May 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ming-Lung YuWan-Long Chuang
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Paul Martin, Donald M Jensen
Jul 29, 2008·The Journal of Infectious Diseases·James FungMan-Fung Yuen
Dec 19, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Nabil Antaki, Patrick Marcellin
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Daniel Lavanchy
Mar 31, 2009·Future Microbiology·Claudio ArgentiniMaria Rapicetta
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Aug 12, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sarah L Fishman, Andrea D Branch
Dec 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Nabil AntakiPatrick Marcellin
Dec 24, 2009·Journal of Medical Virology·Srunthron AkkarathamrongsinYong Poovorawan
May 25, 2010·Journal of Gastroenterology and Hepatology·Owen T-Y TsangThomas S-T Lai
Jun 18, 2010·Journal of Hepatology·Wai-Kay SetoMan-Fung Yuen
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khoa D LamMindie H Nguyen
Nov 3, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandra Mangia
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Philipp de LeuwStefan Zeuzem
Jun 1, 2011·Alimentary Pharmacology & Therapeutics·D T ChaoM H Nguyen
Jun 16, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Di MartinoThierry Thévenot

❮ Previous
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Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Vo Duy ThongYong Poovorawan
May 9, 2014·International Journal of Nanomedicine·Chen-Hua Liu, Jia-Horng Kao
Aug 19, 2014·World Journal of Gastroenterology : WJG·Srunthron AkkarathamrongsinPisit Tangkijvanich
Jul 18, 2014·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Jul 6, 2012·Journal of Viral Hepatitis·C Wartelle-BladouL Lecomte
Feb 3, 2015·Journal of Gastroenterology and Hepatology·Grace Lai-Hung WongVincent Wai-Sun Wong
Feb 27, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seung Kak ShinJu Hyun Kim
Apr 18, 2013·Clinical and Molecular Hepatology·Mun Hyuk SeongKisang Kim
Feb 2, 2019·Journal of Gastroenterology and Hepatology·Grace Lai-Hung WongUNKNOWN Hong Kong Association for the Study of Liver Diseases (HKASLD)
Jan 17, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Roseann S GammalGeorge M Abraham
Sep 28, 2013·World Journal of Hepatology·Chalermrat BunchorntavakulTawesak Tanwandee
Mar 20, 2015·World Journal of Clinical Cases·Vasilios Papastergiou, Stylianos Karatapanis
Jul 29, 2016·World Journal of Gastroenterology : WJG·Nan Nwe WinHiroshi Shirasawa

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