Response inhibition failure to visual stimuli paired with a "single-type" stressor in PTSD patients: an fMRI pilot study

Brain Research Bulletin
Marcella BrunettiC Babiloni

Abstract

Patients with post-traumatic stress disorder (PTSD) tend to misinterpret innocuous stimuli as potential threats, possibly due to a conditioning provoked by traumatic episodes. Previous neuroimaging evidence has shown an abnormal activation of the amygdala and prefrontal cortex in PTSD patients during fear conditioning and extinction. Nevertheless, the effects of a single-type adverse stressor on that circuit remain poorly explored. We tested the hypothesis that a single-type adverse episode is able to affect the prefrontal cortex and amygdala response to conditioned stimuli. To test this hypothesis, fMRI recordings were performed in PTSD patients and trauma-exposed controls during the observation of neutral and negative paired or non-paired pictures with an adverse stimulus by means of a single association. Results showed that left amygdala activation during negative reinforced stimuli was correlated with the score of PTSD clinical scale across all subjects. Furthermore, in the traumatized non-PTSD group, the activation of the dorso-medial prefrontal cortex and bilateral amygdala was lower during the observation of the reinforced (CS(+)) versus non-reinforced pictures (CS(-)) in response to emotionally negative stimuli. This wa...Continue Reading

References

Jan 1, 1981·Psychological Bulletin·M L SpetchJ P Pinel
Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J V HajnalG M Bydder
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E BullmoreP Sham
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jan 1, 1994·Harvard Review of Psychiatry·B A van der Kolk
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jul 12, 2002·European Archives of Psychiatry and Clinical Neuroscience·Anna PissiotaMats Fredrikson
Dec 24, 2003·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Raymond C ChangRalph R Miller
Sep 15, 2004·Neuron·Elizabeth A PhelpsJoseph E LeDoux
Jun 1, 2005·Neural Networks : the Official Journal of the International Neural Network Society·John G Taylor, Nickolaos F Fragopanagos
Oct 11, 2005·Journal of Psychiatric Research·R A LaniusC Pain
Oct 12, 2005·NeuroImage·Leanne M WilliamsRichard A Bryant
Mar 4, 2008·Journal of Psychiatric Research·Mohammed R MiladRoger K Pitman
Apr 11, 2009·European Archives of Psychiatry and Clinical Neuroscience·Claudia CataniFrank Neuner
Sep 15, 2009·Biological Psychiatry·Mohammed R MiladScott L Rauch
Sep 30, 2009·NeuroImage·Marie-Luise MechiasRaffael Kalisch
Apr 22, 2010·CNS Neuroscience & Therapeutics·Ansgar Rougemont-BückingMohammed R Milad
Aug 25, 2010·Depression and Anxiety·Jennifer C BrittonDaniel S Pine
Apr 13, 2011·Cognitive, Affective & Behavioral Neuroscience·Oliver J RobinsonChristian Grillon
Aug 10, 2011·Psychophysiology·Christian Grillon, Danielle R Charney
Feb 9, 2012·Journal of Psychiatry & Neuroscience : JPN·Rebecca K SripadaIsrael Liberzon
Apr 22, 2014·Brain and Cognition·M BrunettiG L Romani

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Citations

May 8, 2018·Harvard Review of Psychiatry·Jacklynn M FitzgeraldK Luan Phan
Dec 9, 2020·Behavioural Brain Research·Jamie N Krueger, Susan Sangha

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