Response latency to lingual taste stimulation distinguishes neuron types within the geniculate ganglion.

Journal of Neurophysiology
Joseph M BrezaR J Contreras

Abstract

The purpose of this study was to investigate the role of response latency in discrimination of chemical stimuli by geniculate ganglion neurons in the rat. Accordingly, we recorded single-cell 5-s responses from geniculate ganglion neurons (n = 47) simultaneously with stimulus-evoked summated potentials (electrogustogram; EGG) from the anterior tongue to signal when the stimulus contacted the lingual epithelium. Artificial saliva served as the rinse solution and solvent for all stimuli [(0.5 M sucrose, 0.03-0.5 M NaCl, 0.01 M citric acid, and 0.02 M quinine hydrochloride (QHCl)], 0.1 M KCl as well as for 0.1 M NaCl +1 μM benzamil. Cluster analysis separated neurons into four groups (sucrose specialists, NaCl specialists, NaCl/QHCl generalists and acid generalists). Artificial saliva elevated spontaneous firing rate and response frequency of all neurons. As a rule, geniculate ganglion neurons responded with the highest frequency and shortest latency to their best stimulus with acid generalist the only exception. For specialist neurons and NaCl/QHCl generalists, the average response latency to the best stimulus was two to four times shorter than the latency to secondary stimuli. For NaCl-specialist neurons, response frequency incr...Continue Reading

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Citations

Oct 12, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly R SmithAlan C Spector
Aug 17, 2012·Journal of Neurophysiology·Joseph M Breza, Robert J Contreras
Dec 30, 2011·Journal of Neurophysiology·Joseph M Breza, Robert J Contreras
Nov 12, 2010·Journal of Neurophysiology·Shiro Nakamura, Robert M Bradley
Aug 11, 2010·The Journal of Cell Biology·Nirupa Chaudhari, Stephen D Roper
May 10, 2012·The Journal of Physiology·Christopher J MacDonaldSidney A Simon
Jul 30, 2011·The Journal of Comparative Neurology·James CorsonAlev Erisir
Oct 6, 2017·Chemical Senses·Thomas G MastRobert J Contreras
Jun 27, 2014·Journal of Neurophysiology·David M Wilson, Christian H Lemon
Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Ranier GutierrezSidney A Simon
Apr 23, 2020·Journal of Neurophysiology·Cecilia G Bouaichi, Roberto Vincis
Nov 3, 2017·Journal of Neurophysiology·Alison BoxwellJoseph B Travers
Aug 17, 2019·Frontiers in Integrative Neuroscience·Michael S WeissPatricia M Di Lorenzo
Nov 23, 2017·Physiology & Behavior·Laura E MartinAnn-Marie Torregrossa
Jun 6, 2021·The Journal of Physiology·Domenico M GuarascioSimone Pifferi

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