Response of asymptomatic brain metastases from small-cell lung cancer to systemic first-line chemotherapy

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Tatjana SeuteAlbert Twijnstra

Abstract

The purpose of this study was to investigate the radiologic response of asymptomatic brain metastases (BM) from small-cell lung cancer (SCLC) to first-line systemic chemotherapy. From 1990 to 2003, 181 consecutive patients with SCLC were enrolled onto this study. Patients were examined by a neurologist on a regular basis. Magnetic resonance imaging (MRI) of the brain was performed routinely before (at diagnosis of SCLC) and after first-line systemic chemotherapy. Patients were treated with combination chemotherapy consisting of cyclophosphamide, doxorubicin, and etoposide. Clinically manifest BM were treated with whole-brain radiotherapy (WBRT). The response rate (RR) of BM was assessed by changes in the size or the number of enhanced lesions on MRI using standard criteria. Synchronous asymptomatic BM were found in 24 SCLC patients (13%). In six (27%) of the 22 assessable patients, the asymptomatic BM responded to systemic chemotherapy. A systemic response was found in 16 patients (73%). All patients became symptomatic during follow-up. The symptom-free survival did not differ between cranial responders and cranial nonresponders. The RR of asymptomatic BM from SCLC to systemic chemotherapy is 27% and evidently lower than the sy...Continue Reading

References

Sep 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A KristensenH H Hansen
Jan 1, 1990·British Journal of Cancer·C J TwelvesD M Geddes
Jul 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LeeW K Hong
Mar 1, 1988·European Journal of Cancer & Clinical Oncology·P E Kristjansen, H H Hansen
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E A NeuweltE P Frenkel
Apr 1, 1984·Southern Medical Journal·H KantarjianM Valdivieso
Jan 1, 1983·Journal of Neuro-oncology·D J StewartT L Loo
Sep 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P E Postmus, E F Smit
Mar 17, 2000·Journal of Neuro-oncology·P D SchellingerA Thron
Feb 13, 2001·Critical Reviews in Oncology/hematology·F GrossiA Ardizzoni
Aug 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A KorfelE Thiel
Oct 3, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J van den Bent
Nov 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wolfgang Schuette

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Citations

Aug 26, 2009·International Journal of Clinical Oncology·Tobias Walbert, Mark R Gilbert
Oct 21, 2011·Current Oncology Reports·Lakshmi NayakPatrick Y Wen
Nov 9, 2007·The New England Journal of Medicine·Anand T Shivnani
Aug 19, 2007·The New England Journal of Medicine·Ben SlotmanUNKNOWN EORTC Radiation Oncology Group and Lung Cancer Group
Jun 10, 2008·The Cancer Journal·William A Castrucci, Jonathan P S Knisely
Jan 17, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Gregory P Kalemkerian
Jul 5, 2007·Neurosurgical Focus·Robert Cavaliere, David Schiff
Oct 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Brett W CarterJeremy J Erasmus
Nov 3, 2006·Expert Review of Neurotherapeutics·Jan Drappatz, Patrick Y Wen
Apr 7, 2010·Expert Review of Neurotherapeutics·Marc C Chamberlain
Jun 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Farkhat ManapovRainer Fietkau
Feb 5, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Geetika SrivastavaYun Oh
Jul 20, 2011·Cancer Treatment Reviews·Jordi RemonSusana Martínez
Nov 27, 2010·Neurosurgery Clinics of North America·Nicholas Butowski
Feb 20, 2008·Clinical Lung Cancer·Gigi ChenDerick Lau
Jan 24, 2007·Clinical Lung Cancer·Amanda L Schwer, Laurie E Gaspar
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Im Il NaJae Cheol Lee
Jun 17, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julio Sánchez de CosManuel Hernández Valle
Oct 30, 2007·Neurologic Clinics·Teri D Nguyen, Lisa M DeAngelis
Nov 5, 2011·Journal of Korean Neurosurgical Society·Kwang Wook JoJung-Il Lee
Sep 9, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yi ChenShunchang Jiao
Jun 15, 2012·The Cochrane Database of Systematic Reviews·Ludovic ReveizAndrés Felipe Cardona
Oct 21, 2017·Oncotarget·Rimas V LukasRavi Salgia
Oct 28, 2017·Japanese Journal of Clinical Oncology·Yoshiro NakaharaNoriyuki Masuda
Jan 25, 2018·Current Treatment Options in Oncology·Jerome J Graber, Santosh Kesari
Nov 30, 2019·Nature Reviews. Cancer·Adrienne BoireManuel Valiente

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