PMID: 11604076Oct 18, 2001Paper

Response of base excision repair enzymes to complex DNA lesions

Radiation Research
M WeinfeldR A Britten

Abstract

There is now increasing evidence that ionizing radiation generates complex DNA damage, i.e. two or more lesions--single-strand breaks or modified nucleosides--located within one to two helical turns on the same strand or on opposite strands. Double-strand breaks are the most readily recognizable clustered lesions, but they may constitute a relatively minor fraction of the total. It is anticipated that clustered lesions may play a significant role in cellular response to ionizing radiation since they may present a major challenge to the DNA repair machinery. The degree of lesion complexity increases with increasing LET. This has potential implications for space travel because of exposure to high-LET cosmic radiation. It is therefore critical that we begin to understand the consequences of such damaged sites, including their influence on DNA repair enzymes. This paper presents a short review of our current knowledge of the action of purified DNA repair enzymes belonging to the base excision repair pathway, including DNA glycosylases and apurinic/apyrimidinic endonucleases, on model complex lesions.

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Citations

Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·M E LomaxP O'Neill
Jun 14, 2002·Experimental Hematology·Nicholas Dainiak
Apr 3, 2008·Journal of Biomedicine & Biotechnology·M Ahmad Chaudhry
Jun 28, 2002·Nucleic Acids Research·Alexandros G GeorgakilasBetsy M Sutherland
Jul 31, 2003·Nucleic Acids Research·Dwain I D'souza, Lynn Harrison
Sep 1, 2005·Nucleic Acids Research·Jason L ParsonsGrigory L Dianov
Feb 1, 2007·Nucleic Acids Research·Jason L ParsonsGrigory L Dianov
May 1, 2007·Nucleic Acids Research·Grégory Eot-HoullierEvelyne Sage
Jul 26, 2008·Nucleic Acids Research·Svitlana MalyarchukLynn Harrison
Oct 28, 2008·Biochemistry·Raphael D HazelCarlos de Los Santos
May 27, 2009·Nucleic Acids Research·Sophie BellonPeter O'Neill
Mar 12, 2010·Journal of the American Chemical Society·Jens VölkerKenneth J Breslauer
May 18, 2010·The Journal of Physical Chemistry. B·Kiran K K SharmaWilliam A Bernhard
May 6, 2008·Journal of Biomedical Science·M Ahmad Chaudhry
Feb 12, 2009·International Journal of Radiation Biology·Peter O'Neill, Peter Wardman
Sep 14, 2010·Seminars in Radiation Oncology·Conchita Vens, Adrian C Begg
Oct 6, 2009·DNA Repair·Svitlana MalyarchukLynn Harrison
Oct 25, 2008·Mutation Research·Somaira NowsheenAlexandros G Georgakilas
Sep 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Tomo SugaTakashi Imai
Feb 3, 2012·Molecular Microbiology·Krzysztofa NagorskaChristoph M Tang
Dec 14, 2004·Journal of Molecular Biology·Svitlana Malyarchuk, Lynn Harrison
Jul 17, 2004·Free Radical Biology & Medicine·Paula V BennettBetsy M Sutherland
Aug 2, 2005·Journal of Molecular Biology·Helen BudworthGrigory L Dianov
Aug 15, 2014·DNA Repair·Shirin RahmanianHooshang Nikjoo

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