Response of biomarkers of inflammation and coagulation to short-term changes in central site, local, and predicted particle number concentrations

Annals of Epidemiology
Christina H FullerDoug Brugge

Abstract

Previous studies have reported acute (hours-28 days) associations between ambient ultrafine particles (UFP; diameter <0.1) and biomarkers of cardiovascular health using central site data. We evaluated particle number concentration (a proxy measure for UFP) measured at a central site, a local near-highway site and predicted residential concentrations with response of biomarkers of inflammation and coagulation in a near-highway population. Participants provided two blood samples for analysis of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α receptor II, and fibrinogen. Mixed effect models were used to evaluate the association between PNC levels on the same day, prior 2 days, and moving averages of 3 to 28 days. Estimated effects on biomarkers of a 5000 unit increase in central site PNC generally increased with longer averaging times for IL-6, hs-CRP, and fibrinogen. Effect estimates were highest for a 28-day moving average, with 91% (95% confidence interval [CI]: 9, 230) higher IL-6 levels, 74% (95% CI: -7, 220) higher hs-CRP levels, and 59% (95% CI: -13, 130) higher fibrinogen levels. We observed no clear trend between near-highway or predicted residential PNC and any of the biomarker...Continue Reading

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Citations

Aug 5, 2016·Environmental Science & Technology·N HuddaJ L Durant
Apr 27, 2017·International Journal of Environmental Research and Public Health·Yu LiDoug Brugge
Mar 31, 2017·Environmental Health : a Global Access Science Source·Emily J EshlemanJaime E Hart
Apr 9, 2020·International Journal of Molecular Sciences·Eleonora Marta LonghinMaurizio Gualtieri
Dec 7, 2018·Journal of Exposure Science & Environmental Epidemiology·Douglas I WalkerKurt D Pennell
Feb 23, 2019·International Journal of Public Health·Simone OhlweinBarbara Hoffmann
Oct 4, 2020·Ecotoxicology and Environmental Safety·Mengqi SunJunchao Duan

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