PMID: 9525779Apr 3, 1998Paper

Response of blood platelets to Proteus mirabilis lipopolysaccharide

Microbiology and Immunology
B WachowiczW Kaca

Abstract

The effects of the lipopolysaccharide (LPS) of Proteus mirabilis on the production of thiobarbituric acid reactive substances (TBARS) and the generation of superoxide radicals (O2) by pig blood platelets were studied in vitro. The effect of LPS on TBARS formation in platelets was dependent on the concentration of endotoxin. LPS at concentrations above 0.1 microg/10(8) platelets caused the production of TBARS concomitant with the generation of superoxide radicals. The responses of platelets to LPS suggest that endotoxin, like thrombin (a strong platelets agonist), stimulates an enzymatic cascade of platelet arachidonate via cyclooxygenase and produces thromboxane A2 (TXA2) concomitant with malonyldialdehyde (MDA).

References

Jul 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M D NavarroM L Pita
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·R I Roth, W Kaca
Aug 25, 1993·JAMA : the Journal of the American Medical Association·M LeviS J van Deventer
Oct 1, 1996·Cardiovascular Research·R S McCuskeyB Urbaschek

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Citations

Jul 29, 2005·Current Microbiology·Joanna Saluk-JuszczakRafał Gowacki
Nov 23, 2006·Infection and Immunity·Christopher J KuckleburgCharles J Czuprynski
Jan 1, 2009·Journal of Oral Microbiology·Steven W Kerrigan, Dermot Cox
Jan 22, 2010·Cellular and Molecular Life Sciences : CMLS·Steven W Kerrigan, Dermot Cox

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