Response of cardiac antioxidant system to alcohol and exercise training in the rat

Alcohol
K Husain, S M Somani

Abstract

Recent evidence has shown that alcohol as well as exercise induces oxidative stress. However, the combination of both on the cardiac antioxidant system is not known. This study investigates the interactive effects of exercise training and chronic ethanol consumption on the antioxidant system of the rat heart. Male Fisher-344 rats were treated as follows: 1) sedentary control (SC); 2) exercise training (ET) for 6.5 weeks; 3) ethanol (2 g/kg, PO) for 6.5 weeks, and 4) ET plus ethanol for 6.5 weeks. Rats were sacrificed and hearts were isolated. Glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), and lipid peroxidation (MDA) were determined in heart tissues. SOD and GSH-Px activities were significantly increased 118% and 148% of SC, respectively, due to ET. GSH level increased 118% of SC in ET rats. GSH-Px activity increased 118% of SC whereas SOD activity and CuZn-SOD protein level and GR activity decreased 87%, 71%, and 90% of SC due to chronic ethanol administration. GSH level decreased 87% of SC and lipid peroxidation increased 149% of SC due to ethanol consumption. GSH-Px activity and GSH levels increased 143% and 130% of SC d...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Oct 20, 1992·Biochemical Pharmacology·C RibièreR Nordmann
Jan 1, 1992·Free Radical Biology & Medicine·R NordmannH Rouach
Apr 1, 1992·Molecular and Cellular Biochemistry·C T KumarP Reddanna
Jan 1, 1991·Chemico-biological Interactions·T Y AwD P Jones
Jun 1, 1990·Journal of Applied Physiology·M H LaughlinR J Korthuis
Apr 1, 1989·Acta Physiologica Scandinavica·M KihlströmA Salminen
Mar 16, 1987·Life Sciences·C M ArdiesR P Farrar
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Mar 1, 1988·Sports Medicine·R R Jenkins
Feb 1, 1985·Medical Hypotheses·K L Nuttall
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Mar 15, 1981·Chemico-biological Interactions·M Younes, C P Siegers
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·S M SomaniL P Rybak
Jan 1, 1994·Advances in Experimental Medicine and Biology·C GuerriJ Renau-Piqueras
Nov 1, 1994·Alcohol·C GeroldiM Trabucchi
Nov 1, 1994·Journal of Applied Physiology·C K SenO Hänninen
Dec 1, 1994·Medicine and Science in Sports and Exercise·C M ArdiesB J Koehn
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SchenkK Schulze-Osthoff
Jan 1, 1994·British Medical Bulletin·V R Preedy, P J Richardson
Jun 1, 1994·Chemico-biological Interactions·M MeyerP A Baeuerle
Feb 1, 1993·Medicine and Science in Sports and Exercise·H M Alessio
Feb 1, 1993·Journal of Clinical Pharmacology·Z V KendrickD T Lowenthal
Feb 1, 1993·Medicine and Science in Sports and Exercise·L L Ji
May 28, 1993·Annals of the New York Academy of Sciences·P Werner, G Cohen
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C K Sen, L Packer
Jan 1, 1996·Free Radical Biology & Medicine·J D KimJ T Herlihy
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Hubert MörkJosef Köhrle

❮ Previous
Next ❯

Citations

Aug 2, 2001·Journal of Applied Toxicology : JAT·R JagannathanS M Somani
Dec 3, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kazim Husain
Jul 27, 2001·Drug and Alcohol Dependence·L VilaA I Alvarez
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kazim Husain
Sep 1, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Kristen Lawton BarryDavid W Oslin
May 19, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M L OjedaO Carreras
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·J KornfehlB Knerer
Mar 30, 2002·Alcoholism, Clinical and Experimental Research·Om PrakashSteve Nelson
Jul 23, 1999·Annals of the New York Academy of Sciences·M Atalay, C K Sen
Feb 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Luciano A da SilvaRicardo A Pinho
Feb 26, 2005·Sports Medicine·Mahmoud S El-SayedZeinab El-Sayed Ali
Oct 16, 2009·Sports Medicine·Andreas N Kavazis
Sep 11, 2012·Cell Biochemistry and Function·Andréia Machado CardosoMaria Rosa Chitolina Schetinger
Sep 30, 2004·Free Radical Biology & Medicine·Karyn L HamiltonScott K Powers
Jul 25, 2006·International Journal of Cardiology·António AscensãoJosé Magalhães
Jan 24, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mustafa GulSenol Dane
Sep 5, 2015·Journal of Oncology·Amy A Kirkham, Margot K Davis
Jun 29, 2010·Ecotoxicology and Environmental Safety·Nejla SoudaniNajiba Zeghal
May 16, 2002·Biochimica Et Biophysica Acta·Kazim Husain, Stephen R Hazelrigg
Apr 10, 2016·The Journal of Physiology·John M LawlerJeffrey M Hord
May 29, 1998·Alcoholism, Clinical and Experimental Research·T K Greenfield
Jan 29, 2009·Integrative Cancer Therapies·Karen Y Wonders, Beverly S Reigle
Jul 12, 2007·Human & Experimental Toxicology·Kazim HusainJainarine Lalla
Apr 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adam J ChiccoReid Hayward
Feb 10, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Kazim HusainJainarine Lalla
Dec 16, 2003·Journal of Applied Physiology·Shannon L LennonScott K Powers
Dec 29, 2000·Medicine and Science in Sports and Exercise·R N DagganZ V Kendrick
Mar 29, 2005·Molecular and Cellular Biochemistry·Kazim Husain, Satu M Somani
Mar 6, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Rick J AllemanDavid A Brown
May 24, 2006·Molecular and Cellular Biochemistry·Kazim HusainJainarine Lalla
May 1, 2021·International Journal of Molecular Sciences·Laia Just-BorràsMaria A Lanuza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jonathon B RyanPeter S Macdonald
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
H MaierA Born
© 2021 Meta ULC. All rights reserved