Response of CEDIA amphetamines assay after a single dose of bitter orange

Therapeutic Drug Monitoring
DiemThuy T NguyenPeter J Ambrose

Abstract

Bitter orange has recently been substituted as an ingredient in many "ephedra-free" dietary supplements used for weight loss. The primary active ingredient in bitter orange is synephrine. Previous reports have documented false-positive results from ephedrine with urine amphetamine assays. Because of the similarity in chemical structure of ephedrine and synephrine, it is hypothesized that ingestion of a bitter orange supplement may have the potential to cause false-positive results with urine amphetamine assays. The purpose of this study was to determine the response of the CEDIA Amphetamines Assay after ingestion of bitter orange. Six healthy adult male volunteers were administered a single oral dose of Nature's Way Bitter Orange, a 900-mg dietary supplement extract standardized to 6% synephrine. Urine specimens were collected at baseline and 3 and 6 hours post-administration. Additional urine specimens were collected from 1 subject at 9, 12, and 15 hours after administration. All specimens were analyzed by the CEDIA Amphetamines Assay. Urine specific gravity and pH also were measured. All urine specimens demonstrated a negative response to the CEDIA Amphetamines Assay. Urine specific gravity ranged from 1.007 to 1.028, and pH ...Continue Reading

References

Mar 1, 1983·The Journal of Pharmacy and Pharmacology·K E IbrahimC M Williams
Jan 1, 1981·Clinical Toxicology·R D Budd
Sep 18, 2004·Journal of the American Pharmacists Association : JAPhA·Peter J Ambrose

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Citations

Mar 6, 2019·Journal of Dietary Supplements·Sidney J Stohs, Sidhartha D Ray

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