PMID: 3759226Oct 1, 1986Paper

Response of cerebral arteries to sympathetic stimulation during acute hypertension

Hypertension
K Tamaki, D D Heistad

Abstract

Our goal was to determine whether sympathetic stimulation during acute hypertension constricts large cerebral arteries and attenuates increases in cerebral microvascular pressure. We measured cerebral blood flow with microspheres and pressure in small pial arteries with a servonull device in anesthetized cats. During moderate hypertension, sympathetic stimulation had little effect on resistance of large or small cerebral vessels. During severe hypertension, sympathetic stimulation prevented passive decreases in resistance of large cerebral arteries and allowed pronounced constriction of small vessels. During hypertension, there was a large increase in pressure in small pial arteries. Although sympathetic stimulation prevented decreases in resistance of large arteries during severe hypertension, it did not attenuate increases in pressure in pial arteries approximately 200 micron in diameter and only modestly attenuated increases in pressure in pial arteries approximately 100 micron in diameter. These findings indicate that sympathetic stimulation has important effects on resistance of both large and small cerebral vessels during severe hypertension. Thus, although stimulation produces dilation of small cerebral vessels during no...Continue Reading

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Citations

Mar 1, 1988·Microvascular Research·W G MayhanD D Heistad
Dec 1, 1992·Pharmacology & Therapeutics·F Plane, C J Garland
Jan 8, 2014·The Journal of Physiology·Christopher K WilliePhilip N Ainslie
Jul 22, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Romain GuibertFranck Plouraboué
Jul 1, 1990·The American Journal of Emergency Medicine·C S GreeneM B Murphy
Aug 1, 2008·The Journal of Headache and Pain·Marcelo M ValençaJosé Geraldo Speciali
Mar 21, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariCalin I Prodan
Jan 1, 1990·Circulation Research·F M Faraci, D D Heistad
Oct 11, 1992·Stroke; a Journal of Cerebral Circulation·G C BauknightD D Heistad
Aug 1, 1988·Hypertension·G L Baumbach, D D Heistad
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·G J BoumaH A Kontos
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·M G MuhonenD D Heistad
Mar 13, 2021·PLoS Computational Biology·Wahbi K El-BouriStephen J Payne

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