Response of emotional unawareness after stroke to antidepressant treatment

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
G SpallettaRobert G Robinson

Abstract

Unawareness of impairment (anosognosia) is a phenomenon associated with right hemisphere lesions. Unawareness of emotion has rarely been studied. Patients (N = 50) with poststroke major depression were administered the Toronto, Ontario, Canada, Alexithymia Scale to assess impairment in identifying feelings (F1), describing feelings (F2), and externally oriented thinking (F3). After eight weeks of treatment with sertraline or fluoxetine, patients were reassessed. Alexithymia was significantly associated with right hemisphere lesions. Patients with alexithymia had a significant improvement in identifying and describing feelings, but not in externally oriented thinking. In addition, cognitive functions improved after antidepressant treatment in patients without alexithymia with left lesions only. On the contrary, functional activities of daily living and depressive symptoms improved both in patients with alexithymia and those without alexithymia. The unawareness of emotions is a common impairment after right hemisphere stroke. This disorder may be significantly improved by antidepressant treatment.

References

Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·S E StarksteinR G Robinson
May 1, 1989·The American Journal of Psychiatry·K Bolla-WilsonT R Price
Jan 1, 1973·Psychotherapy and Psychosomatics·P E Sifneos
May 1, 1996·Psychosomatic Medicine·R D LaneG E Schwartz
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·M KimuraJ T Kosier
Nov 24, 2001·Psychosomatic Medicine·G SpallettaC Caltagirone
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Manuel Sanchez-Alavez, Tamas Bartfai
Oct 14, 2009·Cognitive Neuropsychiatry·Aikaterini Fotopoulou
Jun 10, 2010·International Review of Psychiatry·Maria Donata OrfeiGianfranco Spalletta
Jun 11, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mari E Nurmi Laihosalo, Mervi Jehkonen
Jan 5, 2011·Comprehensive Psychiatry·Sergio ParadisoWilliam Coryell
May 2, 2009·Archives of Physical Medicine and Rehabilitation·Teresa A AshmanBrian Greenwald
Mar 31, 2009·Human Psychopharmacology·Luca CravelloGianfranco Spalletta
May 17, 2008·CNS Neuroscience & Therapeutics·Jop P MostertJacques De Keyser
Nov 7, 2009·Neurological Research·Jing Fang, Qi Cheng
Jun 19, 2007·Topics in Stroke Rehabilitation·Katherine SalterRobert Teasell
May 16, 2014·Applied Neuropsychology. Adult·Ewa Zawadzka, Łucja Domańska
Sep 11, 2008·Neurocase·Ilaria B NardoneOliver H Turnbull
Nov 3, 2015·The Journal of Nervous and Mental Disease·Tai-Hsin HungJian-An Su
Nov 15, 2006·Current Opinion in Neurology·Edward H de HaanMartine J Van Zandvoort
May 4, 2007·International Journal of Geriatric Psychiatry·Gianfranco SpallettaCarlo Caltagirone
Jun 25, 2020·Journal of Clinical and Experimental Neuropsychology·Hannah HobsonNele Demeyere
Mar 8, 2013·Journal of Clinical and Experimental Neuropsychology·Gianna CocchiniNicoletta Beschin
Feb 25, 2021·Neuropsychology Review·Danielle M FynnMichael Weinborn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.