Response of exocrine pancreas to corticosterone and aldosterone after adrenalectomy.

Journal of Steroid Biochemistry
P AllietP C Lee

Abstract

The long-term effect of adrenalectomy (Adx) on the exocrine pancreas was examined in female adult rats. Pancreatic amylase concentration decrease to 50% of the control level starting 10 days after Adx, whereas the levels of trypsinogen and lipase remained unchanged. Replacement studies beginning 24 h after surgery with corticosterone (B, 1 mg/100 g body wt) or aldosterone (ALDO, 8 micrograms/100 g body wt) alone did not prevent the decline in amylase after Adx. However, when both hormones were administered together, pancreatic amylase concentration was maintained at a level similar to that of the control group. Serum corticosterone levels in the rats receiving B alone or B + ALDO were not different, and were comparable to levels found in normal rats. Both ALDO and B, given for 5 days starting 10 days after Adx, were required to restore amylase concentrations toward control values. When spironolactone (SPIRO, 3 mg/100 g body wt), a specific mineralocorticoid receptor blocker was administered bid together with ALDO + B, it blocked the increase in pancreatic amylase seen in ALDO + B treated rats but did not affect the serum corticosterone levels. These results suggest that mineralocorticoids are also involved in modulating the lev...Continue Reading

References

Sep 1, 1975·Endocrinology·L Pressley, J W Funder
Mar 1, 1976·Endocrinology·N S Anderson, D D Fanestil
Jan 1, 1988·Digestion·J MössnerS Stieber
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J MössnerW Fischbach
Feb 1, 1987·Journal of Steroid Biochemistry·R B LuP C Lee
Jan 1, 1986·Neuroendocrinology·B S McEwenA F De Nicola
Nov 1, 1986·Endocrinology·A R BeaudoinA Grossman
Feb 1, 1972·Journal of Steroid Biochemistry·J W FunderI S Edelman
Jun 1, 1972·European Journal of Clinical Investigation·H D Söling, K O Unger
Nov 1, 1961·Archives of Biochemistry and Biophysics·B F ERLANGERW COHEN

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