PMID: 7540086Jan 1, 1995Paper

Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation

Neurourology and Urodynamics
B von HeydenE A Tanagho

Abstract

Prazosin (an alpha-1-adrenergic blocker) and cromakalim (potassium channel opener), given alone, induced significant fatigue of the urethral sphincter at a concentration of 10(-4) M; both drugs combined achieved a significant sphincteric fatigue at a concentration of 10(-5) M each. To 10(-4) M hexamethonium (ganglionic smooth muscle blocker) and 10(-4) M decamethonium (nicotinic blocker of striated muscle) the striated urethral sphincter responded like striated muscle with no detectable function of its smooth muscle component. Therefore, the striated component seems to play a dominant role in sphincteric function. With calcium depletion or in the presence of a calcium channel blocker (10(-4) M nifedipine) the urethral sphincter showed a relative enhancement of response to electrical field stimulation when compared with smooth and skeletal muscle, whose responses were both significantly reduced. This phenomenon could not be explained with calcium-dependent, inhibitory, nitric oxide-releasing nerves, as the NO-synthase blocker N-nitro-L-arginine (10(-5) M to 5 x 10(-5) M) failed to induce the enhancement of sphincter contraction during electrostimulation found with calcium depletion. Still, NO-releasing nerves might play a role i...Continue Reading

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Citations

Mar 10, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Tierney A Lorenz, Cindy M Meston
Mar 1, 1997·The Journal of Urology·R S SutherlandD S Bredt
Oct 6, 2016·Scientific Reports·H C Stephen ChanShuguang Yuan
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Sep 8, 2006·BJU International·Richard D WaltersAlison F Brading
Jun 21, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·A F BradingR McCoy
Sep 25, 2003·American Journal of Physiology. Renal Physiology·Ron J JankowskiDavid A Vorp

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