Response of human artery, vein, and cultured smooth muscle cells to atrial and C-type natriuretic peptides

Critical Care Medicine
L M ZhangW H Newman

Abstract

We determined the response of intracellular cyclic GMP in human arteries and veins and in smooth muscle cells cultured from these vessels to C-type natriuretic peptide in comparison with atrial natriuretic peptide. Repeated-measures analysis of concentration-response curves. Anesthesia research laboratory. Vascular smooth muscle cells from human blood vessels obtained with Institutional Review Board approval and patient consent. Segments of internal mammary artery and saphenous vein were obtained from patients undergoing coronary artery bypass surgery. Smooth muscle cells were cultured from these vessels. Concentration-response curves of intracellular cyclic GMP were determined and analyzed by two-way analysis of variance with repeated measures. In segments of intact saphenous vein, C-type natriuretic peptide was significantly more effective than atrial natriuretic peptide (16-fold increase in cyclic GMP in response to 1 microM of C-type natriuretic peptide vs. six-fold increase in cyclic GMP in response to 1 microM of atrial natriuretic peptide, p < .05). In rings of intact internal mammary artery, 1 microM of atrial natriuretic peptide (26-fold increase in cyclic GMP over basal value) was more effective than 1 microM of c-typ...Continue Reading

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Citations

Mar 25, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J BonattiB Puschendorf
Feb 27, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K L Minerds, J A Donald
Jun 16, 2001·British Journal of Pharmacology·K E Wiley, A P Davenport
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rochus Witthaut
Feb 15, 2001·Critical Care : the Official Journal of the Critical Care Forum·K IkedaT Fukuda
Aug 12, 2014·Regulatory Peptides·Song GuoMessoud Ashina
May 25, 2005·Peptides·Kailash N Pandey
Jul 14, 2005·Fundamental & Clinical Pharmacology·Alphons J H M HoubenPeter W de Leeuw
Jul 4, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S LakshminrusimhaR H Steinhorn

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