Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women

Systems Biology in Reproductive Medicine
Feng-Jing LiangYong Wang

Abstract

The objective of the present study was to investigate the response patterns of insulin-like growth factors (IGFs) and interleukin-6 (IL-6) to ovarian stimulation within 24 h in patients with polycystic ovary syndrome (PCOS) in comparison with normally ovulating women. This controlled prospective clinical study involved 60 women who attended an infertility clinic. For the induction of the ovarian stimulation, fifty-two patients with PCOS and eight control cases were injected with human menopause gonadotropin (hMG) and human chorionic gonadotropin (hCG) during the early follicular phase of the natural or induced menstrual cycle. The blood was sampled before (0h) and 6, 12, 18, and 24 h after the stimulation. Serum levels of estradiol (E2), IGF-I, IGF-II and IL-6 were measured by radioimmunoassay. A significant decrease in serum IGF-II at 12 h was observed after a mixture of hMG and hCG was administered in patients with polycystic ovaries (PCO) including the typical PCOS group and the PCO + OA group (accumulated p < 0.05), while normal women presented a slight decrease (accumulated p < 0.1) 18h after the stimulation. Moreover, all the groups had similar serum levels of IL-6 and IGF-I at all time points. An increase in serum E2 occ...Continue Reading

References

Jan 1, 1995·Human Reproduction·R NahumS G Hillier
Apr 9, 1999·The Journal of Endocrinology·H S Wang, T Chard
May 2, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·B McElhinney, N McClure
Feb 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P G ArtiniA R Genazzani
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Tzu-Hao WangYung-Kuei Soong
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Sami JabaraJerome F Strauss
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Apr 15, 2004·European Journal of Endocrinology·Matthias MöhligChristof Schöfl
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·José L San MillánHéctor F Escobar-Morreale
Sep 25, 2004·Human Reproduction Update·Bruno Lunenfeld
Jan 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Diaa Eldeen M Abd El AalAbdel-Raheim M A Meki
Feb 9, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B BerkerK Kose
Jul 15, 2006·Metabolism: Clinical and Experimental·Alexandros N VgontzasRichard S Legro
Jan 17, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Magdalena Olszanecka-GlinianowiczKatarzyna Klimek
Jan 31, 2008·Expert Reviews in Molecular Medicine·Evanthia Diamanti-Kandarakis

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Citations

Dec 21, 2010·Fertility and Sterility·Héctor F Escobar-MorrealeFrank González

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