Response of metastatic mucosal melanoma to immunotherapy: It can get worse before it gets better

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Shebli AtrashFade Mahmoud

Abstract

Immune therapy with checkpoint inhibitors has revolutionized the management of metastatic melanoma. Ipilimumab, nivolumab, and pembrolizumab are all FDA-approved immune checkpoint inhibitors to treat metastatic melanoma. Responses to immune checkpoint inhibitors are usually delayed. An interim progression on restaging computed tomography scans "pseudo-progression" may be observed before response to treatment occur. In this case, we report a significant interim progression of metastatic mucosal melanoma before meaningful responses to immunotherapy occurred. The patient developed significant immune therapy-related colitis and new onset vitiligo. Further restaging computed tomography scans showed sustained tumor response despite stopping the immune therapy.

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Citations

Feb 7, 2017·Expert Review of Anticancer Therapy·Inês Anselmo Da CostaJens Bedke
Mar 31, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Fade MahmoudJohn Vander Schilden
Apr 18, 2018·The Journal of Clinical Investigation·Xichen ZhengYuhui Huang
May 18, 2017·Cancer Biology & Therapy·Fade MahmoudAlan J Tackett

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Methods Mentioned

BETA
biopsy
biopsies

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