PMID: 9531393Apr 8, 1998Paper

Response of physeal cartilage to low-level compression and tension in organ culture

Journal of Pediatric Orthopedics
K P Mankin, D J Zaleske

Abstract

The clinical response of growth plate to exogenous forces is well recognized, although the organ-level mechanisms are poorly understood. Physeal cartilage from 5- to 7-day-old bovine distal radii was subjected to 245 N of tension or 245 N of compression (0.012 MPa) in organ culture over a 24-h period. Eleven specimens (six tension, five compression) were assayed for cellular proliferation with tritiated thymidine. Eighteen specimens (12 tension, six compression) were assayed for synthetic activity with radioactive sulfate. Media were assayed for prostaglandin production. Tension increased whereas compression decreased synthetic activity and prostaglandin production by physeal cartilage in explant culture over a 24-h period. There was no significant change in thymidine uptake. Physeal cartilage can respond to both tension and compression and, in the short term, appears to alter synthetic activity without changing the rate of cell proliferation. This study system allows local sampling and manipulation of the physeal organ environment and may lead to ways of approaching growth-plate pathologies in vivo.

References

Sep 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J J ParkkinenM Tammi
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SahJ D Sandy
Sep 1, 1989·Journal of Pediatric Orthopedics·F GrecoM Mannarini
May 1, 1986·Plastic and Reconstructive Surgery·H NettelbladA J Weiland
Aug 1, 1986·Arthritis and Rheumatism·J Klein-NulendE H Burger
Jan 3, 1980·Biochimica Et Biophysica Acta·D SomjenA Harell

❮ Previous
Next ❯

Citations

Feb 8, 2005·Biochemical and Biophysical Research Communications·Christine A ClarkMichael J Zuscik
Sep 24, 2004·Experimental Cell Research·Tian-Fang LiRegis J O'Keefe
Jul 14, 2004·The Journal of Hand Surgery·Takahiro MatsunoMitsuo Ochi
Sep 25, 2007·Journal of Dental Research·S KyrkanidesJ E Puzas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
R J O'KeefeR N Rosier
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Ann Marie SimonJ Patrick O'Connor
© 2022 Meta ULC. All rights reserved