Response of psoriasis to psoralen-UVB photochemotherapy

The British Journal of Dermatology
A SakuntabhaiP M Farr

Abstract

The effect of psoralen in combination with 311 nm (UVB) radiation was studied in five subjects with normal skin and 10 patients with psoriasis involving both forearms. Treatment with oral 8-methoxypsoralen augmented the UVB erythemal response at 6 h after irradiation, but had no effect at 24-72 h. In eight of the nine patients who completed the trial, lesions of psoriasis on the arms treated with psoralen-UVB cleared before lesions on the arms treated with UVB alone. This study has shown that psoralen in combination with UVB has an erythemal effect on normal skin, and a therapeutic effect in psoriasis which is greater than the response to UVB alone.

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Citations

Aug 25, 1999·Journal of the American Academy of Dermatology·A TanewH Hönigsmann
Oct 6, 1997·Clinics in Dermatology·T S Nee
Dec 23, 1998·Clinical and Experimental Dermatology·J M Wishart
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Aug 26, 2004·The British Journal of Dermatology·S H IbbotsonUNKNOWN British Association of Dermatologists
Sep 15, 2009·Photodermatology, Photoimmunology & Photomedicine·Dilek SeckinAsli Senol
Jan 27, 2006·Photodermatology, Photoimmunology & Photomedicine·M El MoftyM Fawzi
Nov 15, 2006·Photodermatology, Photoimmunology & Photomedicine·Noppadol Amornpinyokeit, Pravit Asawanonda
Jan 10, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·P AsawanondaC Nimnuan
Oct 15, 2013·Photodermatology, Photoimmunology & Photomedicine·Shivani BansalVijay Garg
Apr 1, 1997·Journal of the American Academy of Dermatology·D A de BerkerP M Farr
Feb 22, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·P S HemneV Singh

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