Response of retinal vessel diameters to flicker stimulation in patients with early open angle glaucoma

Journal of Glaucoma
G GarhöferG T Dorner

Abstract

Diffuse luminance flicker increases retinal vessel diameters in animals and humans, indicating the ability of the retina to adapt to different metabolic demands. The current study seeks to clarify whether flicker-induced vasodilatation of retinal vessels is diminished in glaucoma patients. Thirty-one patients with early stage glaucoma (washout for antiglaucoma medication) and 31 age- and sex- matched healthy volunteers were included in the study. Retinal vessel diameters were measured continuously with a Retinal Vessel Analyzer. During these measurements three episodes of square wave flicker stimulation periods (16, 32, and 64 secs; 8 Hz) were applied through the illumination pathway of the retinal vessel analyser. Flicker-induced vasodilatation in retinal veins was significantly diminished in glaucoma patients as compared with healthy volunteers (ANOVA, P < 0.01). In healthy volunteers, retinal venous vessel diameters increased by 1.1 +/- 1.8% (16 seconds, P < 0.001), 2.0 +/- 2.6 (32 seconds, P < 0.001), and 2.1 +/- 2.1% (64 seconds, P < 0.001) during flicker stimulation. In glaucoma patients, venous vessel diameters increased by 0.2 +/- 1.7% (16 seconds, P < 0.6), 1.1 +/- 2.1% (32 seconds, P < 0.01), and 0.8 +/- 2.5 (64 secon...Continue Reading

References

Jul 22, 1991·Neuroscience Letters·C E RivaB L Petrig
Jan 1, 1990·Eye·A Bill, G O Sperber
Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·F C DeloriJ J Weiter
Jan 1, 1994·Eye·H C ChenE M Kohner
Jan 1, 1994·The British Journal of Ophthalmology·S M RassamE M Kohner
Jul 1, 1996·Microvascular Research·D G BuerkS D Cranstoun
Jan 14, 1998·Current Eye Research·F FormazM Geiser
Aug 5, 2000·Progress in Retinal and Eye Research·D C Hood
Oct 26, 2000·The British Journal of Ophthalmology·K PolakL Schmetterer
Apr 5, 2001·Progress in Retinal and Eye Research·J FlammerT Resink
Jul 17, 2001·Acta Ophthalmologica Scandinavica·A HarrisH J Garzozi
Aug 2, 2002·Progress in Retinal and Eye Research·Josef FlammerEinar Stefánsson
May 14, 2003·Archives of Ophthalmology·John L KeltnerUNKNOWN Ocular Hypertension Treatment Study Group

❮ Previous
Next ❯

Citations

Oct 20, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K GugletaS Orgul
Feb 19, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K GugletaS Orgul
Jun 21, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Anja M Palmowski-WolfeKlaus W Ruprecht
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Vittorio PorciattiWilliam Buchser
Aug 13, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·L RammM Hammer
Dec 5, 2009·Current Eye Research·Thanh T NguyenTien Y Wong
Apr 30, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Alon HarrisBrent Siesky
Aug 22, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eric A Newman
Sep 25, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stefan PalkovitsGerhard Garhöfer
Dec 6, 2007·Survey of Ophthalmology·Konstantin GugletaSelim Orgül
May 30, 2008·Acta Ophthalmologica·Hemma ReschLeopold Schmetterer
Sep 25, 2012·Acta Ophthalmologica·Stephanie MroczkowskaDoina Gherghel
Dec 22, 2004·Progress in Retinal and Eye Research·Charles E RivaBenedetto Falsini
Mar 25, 2016·Acta Ophthalmologica·Nicolas Philipp WaldmannKonstantin Gugleta
Sep 27, 2013·Journal of Pharmacological Sciences·Tsutomu NakaharaKunio Ishii
Sep 27, 2012·Current Opinion in Pharmacology·A Popa CherecheanuL Schmetterer
Apr 8, 2014·Progress in Retinal and Eye Research·Rainer A LeitgebLeopold Schmetterer
Jul 21, 2011·Microvascular Research·Gerhard GarhöferLeopold Schmetterer
Mar 3, 2015·Journal of Pharmacological Sciences·Asami MoriKunio Ishii
Jan 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Doreen SchmidlAlina Popa-Cherecheanu
Dec 22, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Constantin J Pournaras, Charles E Riva
Sep 24, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Peter JeppesenToke Bek
Aug 4, 2018·Retina·Alessandro RabioloGiuseppe Querques
Oct 30, 2014·The Open Ophthalmology Journal·Michael Selbach JStephan Kremmer
Oct 16, 2014·The Open Ophthalmology Journal·S KremmerJ M Selbach
Jul 14, 2020·Frontiers in Cell and Developmental Biology·Lauren K Wareham, David J Calkins
Jul 30, 2014·The Open Ophthalmology Journal·Stephan KremmerMichael Selbach J
Sep 5, 2020·Journal of Clinical Medicine·Garhöfer GerhardLeopold Schmetterer
Jul 14, 2020·Progress in Retinal and Eye Research·Gala BeykinJeffrey L Goldberg
Aug 28, 2021·Cells·Valery I ShestopalovMarkus H Kuehn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.