Response of selenium status indicators to supplementation of healthy North American men with high-selenium yeast

Biological Trace Element Research
Wayne Chris HawkesEllen L Bonnel

Abstract

The essential nutrient selenium is required in microgram amounts [recommended dietary allowance (RDA) = 55 microg/day, 699 nmol/day] and has a narrow margin of safety (upper tolerable intake limit = 400 microg/day, 5 micromol/day). We conducted a randomized placebo-controlled study of high-selenium yeast, the form used in most supplements (300 microg/day, 3.8 micromol/day), administered to 42 free-living healthy men for 48 weeks. Dietary intakes of selenium, macronutrients, and micronutrients were not different between groups and did not change during the study. Supplementation more than doubled urinary selenium excretion from 69 to 160 microg/day (876 to 2,032 nmol/day). Urinary excretion was correlated with recent selenium intake estimated from 3-day diet records: urinary selenium excretion = 42 microg/day (533 nmol/day) + 0.132 x dietary selenium intake, p < 0.001. Dietary selenium intake was not significantly correlated with the other indicators of selenium status, presumably because urinary selenium excretion reflected recent intake, and tissue selenium was homeostatically controlled. After 48 weeks of supplementation, plasma selenium was increased 60% from 142 to 228 microg/l (1.8 to 2.9 micromol/l), and erythrocyte selen...Continue Reading

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Citations

Aug 21, 2013·Biological Trace Element Research·Wayne Chris HawkesZeynep Alkan
Feb 26, 2010·The American Journal of Clinical Nutrition·Rachel HurstSusan J Fairweather-Tait
Feb 4, 2011·The Journal of Nutrition·Meryl E WastneyBlossom H Patterson
Jun 4, 2014·International Journal of Hygiene and Environmental Health·Nolwenn NoiselMichèle Bouchard
Jul 11, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Irena MusikJoanna Kocot
Jan 21, 2016·BMC Veterinary Research·Mariëlle van ZelstGeert P J Janssens
Apr 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dietrich BehneAntonios Kyriakopoulos
May 1, 2010·Environmental Toxicology and Pharmacology·Nolwenn NoiselGaétan Carrier
Sep 15, 2009·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wayne Chris HawkesZeynep Alkan
Jul 6, 2014·Critical Reviews in Food Science and Nutrition·Ma Gorzata BodnarJacek Namieśnik
Mar 2, 2017·International Journal of Molecular Sciences·Kazuaki TakahashiYasumitsu Ogra
May 8, 2009·The American Journal of Clinical Nutrition·Kate AshtonSusan J Fairweather-Tait
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Nov 9, 2017·Environmental Health Perspectives·Helena SkröderMarie Vahter
Oct 4, 2018·Current Environmental Health Reports·Marco VincetiLauren A Wise
Nov 28, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wayne Chris Hawkes, Lawrence J Laslett
Oct 21, 2018·Environment International·Helena SkröderMarie Vahter

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