Response of serum macrophage migration inhibitory factor levels to stimulation or suppression of the hypothalamo-pituitary-adrenal axis in normal subjects and patients with Cushing's disease

The Journal of Clinical Endocrinology and Metabolism
A M IsidoriA B Grossman

Abstract

Macrophage migration inhibitory factor (MIF) is a proinflammatory pituitary and immune cell cytokine and a critical mediator of septic shock. It has been reported that MIF is secreted in parallel with ACTH from the pituitary in response to stress or inflammatory stimuli. MIF release from immune cells is also induced rather than inhibited by glucocorticoids. It has therefore been suggested that MIF may be a novel counterregulatory hormone of glucocorticoid action that acts both as a paracrine and endocrine modulator of host responses. We have measured circulating MIF levels, using a human MIF ELISA, in normal subjects and patients under numerous pathophysiological conditions. Serum MIF was measured in normal subjects who underwent stimulation of the hypothalamo-pituitary-adrenal axis with an insulin tolerance test (n = 8), a CRH-stimulation test (n = 5), a short synacthen test (n = 5), and following a low-dose dexamethasone suppression test (n = 6). We also sampled from a peripheral vein and both inferior petrosal sinuses before and after CRH stimulation in four patients with a histologically proven diagnosis of Cushing's disease. Immunostaining of the pituitary tumors for MIF was also performed. In normal subjects serum MIF lev...Continue Reading

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Citations

Nov 24, 2011·International Journal of Biological Sciences·Juan de Dios Rosado, Miriam Rodriguez-Sosa
Nov 22, 2008·Journal of Neural Transmission·L de la FontaineP Zwanzger
Aug 4, 2009·Cytokine·Lin LengRichard Bucala
Mar 30, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T S ChurchB P Giroir
Nov 28, 2007·Immunology and Cell Biology·Alex Kudrin, David Ray
Nov 4, 2009·The Journal of Eukaryotic Microbiology·David BassThomas A Richards
Feb 7, 2006·Biochemistry. Biokhimii︠a︡·O A CherepkovaB Ya Gurvits
Dec 7, 2017·Endocrinology·Isabella FincoGary D Hammer

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