Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Sascha HeinitzS B Votruba

Abstract

Spendthrift vs. thrifty individuals expend more energy and experience greater weight loss during caloric restriction (CR). Adaptive mechanisms in skeletal muscle, adipose tissue, and on hormone level modulate energy expenditure (EE) during weight loss. Metabolic mechanisms underlying the variability in EE during CR are unclear. The present study explored whether during long-term CR (i) gene expression changes in skeletal muscle and adipose tissue relate with the individual EE response and weight loss, and (ii) altered catecholamine and FGF21-concentrations are associated with measures of metabolic adaptation. In a 10-week inpatient study, 24-h EE was measured before and after 6 weeks of 50% CR in 12 subjects using whole-room indirect calorimetry. Weight loss was assessed and repeated hormone measurements performed. Muscle and adipose tissue biopsies were taken before and after CR, and gene expression was assessed (RNA-Seq). Genes showing the most significant changes after CR were tested for association with EE and followed-up for further association with metabolic measures in a separate phenotyping study (n = 103). Muscle UCP2 showed the strongest change after CR (log2-fold change = -1.57, false discovery rate = 0.10) and was c...Continue Reading

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Citations

Apr 24, 2019·Obesity·Paolo Piaggi
Feb 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Lisa ChuJill K Hamilton
Feb 15, 2020·Experimental Gerontology·Jasper Most, Leanne Maree Redman
Apr 7, 2020·Molecular and Cellular Endocrinology·Mayara S OliveiraBianca M de Souza

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Methods Mentioned

BETA
RNA-Seq
X-ray
biopsies
biopsy

Clinical Trials Mentioned

NCT00687115
NCT00340132

Software Mentioned

SAS

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