PMID: 6983307Jul 1, 1982Paper

Response of the endolymphatic sac in the guinea pig to neomycin ototoxicity

American Journal of Otolaryngology
R F GrayF Wilson

Abstract

The guinea pig provides an excellent model for studying the effects of ototoxic antibiotics on the epithelium of the endolymphatic sac (ELS). Intracochlear injection of neomycin produces consistent destruction of cochlear and vestibular sensory cells, and the response to this traumatic insult can be documented by light and electron microscopy of the ELS. The histologic findings suggest that ELS epithelial cells are relatively resistant to ototoxic levels of neomycin. The study confirms the ability of the ELS to increase its activity during periods of labyrinthine stress.

References

Sep 16, 1976·Archives of Oto-rhino-laryngology·P G Lundquist
Sep 1, 1974·The Annals of Otology, Rhinology, and Laryngology·R A SchindlerM D Morrison

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Citations

Nov 1, 1989·American Journal of Otolaryngology·M HultcrantzD Bagger-Sjöbäck
May 1, 1984·American Journal of Otolaryngology·C G Wright, W L Meyerhoff
Jun 9, 1998·Annals of the New York Academy of Sciences·M BarbaraR Filipo
May 1, 1984·Acta Oto-laryngologica·S Saijo, R S Kimura

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