Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the rat

Movement Disorders : Official Journal of the Movement Disorder Society
T González-HernándezManuel Rodríguez

Abstract

Although dopamine is the main neurotransmitter in the mesostriatal system, recent studies indicate the existence of two nigrostriatal GABAergic projections: one arising from neurons immunoreactive for GABA, glutamic acid decarboxylase (GAD67), and parvalbumin (PV) lying in the substantia nigra pars reticulata (nigrostriatal GABA cells) and the other arising from a subpopulation of dopaminergic neurons lying in the substantia nigra pars compacta and ventral tegmental area, which under normal conditions, contains mRNA for GAD65 (one of the two isoforms of glutamic acid decarboxylase), but which is not immunoreactive for GABA and GAD65 (nigrostriatal dopaminergic [DA]/GABA cells). With the aim of improving our knowledge about the interaction between the nigrostriatal system of both brain hemispheres, we have studied the response of these three components of the mesostriatal system (GABA, DA/GABA, and DA) to the lesion of the contralateral mesostriatal DA pathway, by using morphological and neurophysiological techniques. Our findings show that, in the side contralateral to the lesion, (1) the number of nigrostriatal GABA cells increases from 6% to 17% with respect to the total number of nigrostriatal cells, (2) the soma of DA/GABA ...Continue Reading

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Citations

Mar 1, 2012·Journal of Neural Transmission·P Riederer, J Sian-Hülsmann
Oct 5, 2012·Nature·Nicolas X TritschBernardo L Sabatini
Feb 14, 2015·Aging Cell·Manuel RodriguezMagdalena Sabate
Jun 27, 2014·Frontiers in Systems Neuroscience·Ilana Molochnikov, Dana Cohen
Jan 24, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Diego Luis-RaveloTomas Gonzalez-Hernandez
Mar 12, 2010·Brain Research·Roberta Cavalcanti-KwiatkoskiElaine Del Bel

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