Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age

Annals of the New York Academy of Sciences
Franklin RosenfeldtSalvatore Pepe

Abstract

The aging heart has an impaired response to many kinds of stress. In clinical practice, there is a need for senescence-specific therapies to protect against stress and for biochemical markers of senescence to identify those patients most in need of therapy. In isolated rat hearts, in human tissues, and in a clinical trial, we have shown previously that coenzyme Q(10) has the ability to protect the heart against stress especially in senescence. We recently have devised a regimen of therapy to protect the senescent heart against stress, combining metabolic therapy (coenzyme Q(10), alpha lipoic acid, magnesium orotate, and omega 3 polyunsaturated fatty acids) with physical exercise and mental stress reduction. The preliminary results of this program are promising. In an endeavor to predict the likely response of individual senescent hearts to stress, we correlated the tissue load of mitochondrial DNA deletions and total cellular mitochondrial DNA copy number in human cardiac tissue with recovery of the same tissue from ischemia/reperfusion stress. We found that these mitochondrial markers actually were less predictive of impaired response to stress than age alone. We conclude that the aging heart has a diminished capacity to recov...Continue Reading

References

Sep 16, 1991·Biochemical and Biophysical Research Communications·M HayakawaT Ozawa
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C A CaldaroneS Levitsky
Jul 1, 1994·Journal of the American College of Cardiology·A A JaegerS R Gortner
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Franklin RosenfeldtSalvatore Pepe

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Citations

Sep 18, 2008·Biological Trace Element Research·Robyn LymburyAnthony V Perkins
Sep 29, 2006·Anesthesiology·Stanley Muravchick, Richard J Levy
May 25, 2013·Journal of Proteomics·Andreas Simm
May 13, 2008·Experimental Gerontology·Salvatore PepeFranklin L Rosenfeldt
Jul 13, 2004·Annals of the New York Academy of Sciences·Konstantin KhrapkoYevgenya Kraytsberg
Jun 29, 2006·Annals of the New York Academy of Sciences·Sorin RigaFlorin Halalau
May 9, 2009·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Larry N Thibos

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