Response of transmural electrical parameters across in vitro everted sacs of hamster jejunum to variations in oxygenation rate.

Biochimica Et Biophysica Acta
M C Dugas, R K Crane

Abstract

1. The response of the electrical potential difference, short circuit current, and resistance across everted sacs of hamster jejunum to variations in the mucosal solution gassing rate was investigated. 2. Contrary to previous reports by others, it was found that the potential difference responds to increases in mucosal solution gassing rate by increasing in magnitude during the first 20 min of incubation. 3. The increases in potential difference were parallelled by increases in short circuit current but not by changes in resistance. 4. Increases in mucosal solution gassing rate increased epithelial cell O2 availability and this effect was determined to be due to increased stirring by gas bubbles. From the data, it was deduced that the minimum thickness of the mucosally located functional unstirred layer is between 0.08 and 0.16 cm when less than the full magnitude of electrical activity is observed across the everted sac preparation. 5. Serosal N2 or O2 had little or no effect on electrical parameters under maximum mucosal oxygenating conditions but dramatically affected these parameters when less than maximum mucosal oxygenating conditions were used. 6. Qualitative variations in the magnitude of the short circuit current acros...Continue Reading

References

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Citations

Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·D Winne
Apr 1, 1982·Pflügers Archiv : European journal of physiology·I T Johnson, J M Gee
Feb 1, 1979·Archives internationales de physiologie et de biochimie·A FaelliV Capraro

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