PMID: 2112618Mar 1, 1990Paper

Response of tumor and host to hyperalimentation and antiglutamine treatments

JPEN. Journal of Parenteral and Enteral Nutrition
W T ChanceJ E Fischer

Abstract

In two experiments, treatment of tumor-bearing (TB) rats with the glutamine antimetabolite, acivicin, reduced tumor growth during 14 days of total parenteral nutrition (TPN) that supplied 120% and 130% of the nutritional intake of non-TB control rats. The acivicin treatment or combination of acivicin with TPN produced increased carcass weights and decreased tumor/carcass ratios. Significant muscle saving was observed in TB rats receiving TPN or TPN and acivicin as compared to acivicin-treated TB rats maintained on rat chow. Tumor growth was not stimulated by TPN at 130% of ad libitum. intake with a calorie/nitrogen ratio of 102:1. However, when the calorie/nitrogen ratio was increased to 143:1, tumor growth was increased by TPN at 120% of ad libitum. intake. These results suggest that acivicin may prove useful in the stabilization of tumors in situations where tumor growth may be stimulated, such as during TPN.

Citations

Sep 12, 2000·Current Gastroenterology Reports·A L Buchman
Jan 1, 1993·Nutrition and Cancer·A StallionJ E Fischer
Jan 1, 1995·Nutrition and Cancer·W T ChanceJ E Fischer
Dec 1, 1993·Annals of Surgery·W W Souba
Jun 1, 1995·Gastroenterology·A Buchman
Mar 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·A StallionJ E Fischer
Jun 1, 1996·Journal of the American College of Nutrition·A L Buchman
Jul 14, 2001·The American Journal of Clinical Nutrition·A L Buchman
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·A M EassonB P Bode
Nov 1, 1996·American Journal of Surgery·V S Klimberg, J L McClellan

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