Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration

Brain Research
Lidia I SerovaEsther L Sabban

Abstract

The effect of different dose, mode and duration of estradiol administration was examined in the different brain catecholaminergic areas in ovariectomized (OVX) female rats. We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in biosynthesis as well as of tetrahydrobiopterin (BH4), and concentration of BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase. Short-term administration of estradiol benzoate (EB) by five injections of 15 or 40 microg/kg 12 h apart led to increase in TH and GTPCH mRNA levels in dopaminergic and noradrenergic cell bodies of the ventral tegmental area (VTA), substantia nigra (SN), locus coeruleus (LC) and the nucleus of solitary tract (NTS) depending on dose of administration. Estrogen-elicited alterations in BH4 concentrations were mostly correlated with changes in GTPCH mRNA levels, except in SN. Long-term administration of estradiol by injections (EB: 25 microg/kg, 16 injections 26 h apart; 50 microg/kg, 16 injections 48 h apart) or pellets (0.1 mg 17 beta-estradiol, 14 days) were not very effective in modulating mRNA levels for both genes...Continue Reading

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Citations

Jul 21, 2007·Acta Pharmacologica Sinica·Chang LiuMin Hong
Mar 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pandu R R GangulaPankaj Jay Pasricha
Mar 30, 2010·The Journal of Endocrinology·Lidia I SerovaEsther L Sabban
Jan 6, 2012·Canadian Journal of Physiology and Pharmacology·Helena L GomesMargareth R Moysés
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Jul 30, 2009·Physiology & Behavior·Esther L SabbanLidia I Serova
Jul 4, 2009·Neuroscience Letters·Christian WiderMatthew J Farrer
Mar 24, 2009·Life Sciences·Osamu NakagawasaiTakeshi Tadano
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